Dermatomyositis‐like muscle pathology in patients with chronic graft‐versus‐host disease

Allen, Jeffrey A.; Greenberg, Steven A.; Amato, Anthony A.

doi:10.1002/mus.21353

Cited by 19 publications

(25 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Laboratory associations with IMPP pathology include serum anti-tRNA synthetase antibodies, especially Jo-1 [21], and selectively elevated aldolase with normal creatine kinase [14]. Similar perimysial pathology occurs in graft-versus-host disease [14,22], fasciitis [21,23] and some toxic myopathies, but not in hereditary myopathies.…”

Section: Immune Myopathies With Perimysial Pathologymentioning

confidence: 96%

Acquired immune and inflammatory myopathies

Pestronk

2011

Current Opinion in Rheumatology

130

109

View full text Add to dashboard Cite

show abstract

Section: Immune Myopathies With Perimysial Pathologymentioning

confidence: 96%

Acquired immune and inflammatory myopathies

Pestronk

2011

Current Opinion in Rheumatology

130

109

View full text Add to dashboard Cite

show abstract

“…The changes in skeletal muscle range from mild perimysial lymphocytic infiltrates to extensive endomysial inflammation with necrosis and regeneration of fibers. Clinical presentations and pathologic changes resembling both polymyositis and dermatomyositis have been reported [145, 146]. …”

Section: Histological Criteria For the Diagnosis Of Gvhdmentioning

confidence: 99%

NIH Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: II. The 2014 Pathology Working Group Report

Shulman

Cardona

Greenson

et al. 2015

Biology of Blood and Marrow Transplantation

250

242

View full text Add to dashboard Cite

The 2005 National Institute of Health (NIH) Consensus Conference outlined histopathological diagnostic criteria for the major organ systems affected by both acute and chronic graft-versus-host disease (GVHD). The 2014 Consensus Conference led to this updated document with new information from histopathological studies of GVHD in the gut, liver, skin and oral mucosa and expanded discussion of GVHD in the lungs and kidneys. The recommendations for final histological diagnostic categories have been simplified from 4 categories to 3: no GVHD, possible, and likely GVHD based on better reproducibility achieved by combining the previous categories of consistent with and definite GVHD into the single category of likely GVHD. Issues remain in the histopathological characterization of GVHD, particularly with respect to the threshold of histological changes required for diagnostic certainty. Guidance is provided for the incorporation of biopsy information into prospective clinical studies of GVHD, particularly with respect to biomarker validation.

show abstract

“…In PM, with cGVHD, there is fiber size variability, and there are scattered necrotic and regenerating fibers. Endomysial inflammatory infiltrates are mostly CD8+ T‐cells and macrophages . Reports of cGVHD‐associated PM and DM are limited and controversial.…”

Section: Polymyositis and Dermatomyositismentioning

confidence: 99%

Neuromuscular complications of hematopoietic stem cell transplantation

Ruzhansky

Brannagan

2015

Muscle and Nerve

View full text Add to dashboard Cite

Neuromuscular diseases such as polymyositis, dermatomyositis, peripheral neuropathy, and disorders of neuromuscular transmission are reported to be complications of hematopoietic stem cell transplantation (HSCT). Although cases have been reported with allogeneic HSCT in the setting of chronic graft versus host disease, they are also known to occur without evidence thereof and even occur in the setting of autologous HSCT. The 2005 National Institutes of Health Consensus Criteria classify polymyositis and dermatomyositis as "distinctive" features, and neuropathy and MG as "other" features. These neuromuscular complications present very similarly to the idiopathic autoimmune disorders and respond to similar treatment modalities.

show abstract

Dermatomyositis‐like muscle pathology in patients with chronic graft‐versus‐host disease

Cited by 19 publications

References 28 publications

Acquired immune and inflammatory myopathies

Acquired immune and inflammatory myopathies

NIH Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: II. The 2014 Pathology Working Group Report

Neuromuscular complications of hematopoietic stem cell transplantation

Contact Info

Product

Resources

About