Dermatomyositis Sine Myositis with Membranoproliferative Glomerulonephritis

Abstract

Dermatomyositis (DM) is an autoimmune disease that is characterized by involvement of proximal musculature and skin. We report a 52-year-old woman with a 6-year history of dermatomyositis sine myositis, who developed lower extremity edema and proteinuria. Pathological examination of renal biopsy showed membranoproliferative glomerulonephritis. She received steroid, cyclophosphamide, and mycophenolate mofetil. Over the 9 to 10 months after the beginning of treatment, the proteinuria was improved.

Nephrotic Syndrome as an Extramuscular Manifestation of Anti-EJ Antibody-Positive Dermatomyositis: A Case Report and Review of the Literature

“…As for the study by Couvrat-Desvergnes et al, they identified 14 patients who had undergone renal biopsy (6 PM, 5 DM, and 3 ASS), which revealed the presence of glomerulonephritis with various pathologic patterns including immune complex-related glomerulonephritis (n � 4), membranous nephropathy (n � 2), and IgA nephropathy (n � 2) [5]. We conducted an additional literature search and retrieved case reports describing the association of PM or DM with a variety of pathological glomerular lesions, including mesangial proliferative glomerulonephritis [21][22][23][24][25], membranous nephropathy [26][27][28][29][30][31], membranoproliferative glomerulonephritis [32], IgA nephropathy [33][34][35][36][37], diffuse proliferative glomerulonephritis [38], immune complex-type glomerulonephritis [39][40][41][42], acute interstitial nephritis [43], lipoid nephrosis and focal glomerulosclerosis [44], focal segmental glomerulosclerosis with evidence of acute tubular injury [45], sclerotic GN with fibrocellular crescent [46], and crescentic glomerulonephritis associated with malignancy [47]. Cases presenting with anti-neutrophil cytoplasmic antibody-associated glomerulonephritis in the context of DM have also been reported [48][49][50].…”