Dermatopathic lymphadenitis in HIV

Vanisri, HR; Nandini, N M; Gujral, Sumeet; Manjunath, GV

doi:10.4103/0253-7184.62767

Cited by 7 publications

(5 citation statements)

References 7 publications

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“…19 Although it is not commonly reported, dermatopathic lymphadenopathy may be associated with HIV infection and immunohistochemistry should be considered for a definitive diagnosis. 20 In this study, a case of HIV-positive patient was diagnosed as dermatopathic lymphadenopathy due to histological and immunohistochemical findings.…”

Section: Discussionmentioning

confidence: 96%

Correlation Between Clinical and Histological Features of Dermatopathic Lymphadenopathy: Analysis of 39 Lymph Nodes

et al. 2023

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Background. Dermatopathic lymphadenopathy is a well-defined histopathological entity with an underestimated prevalence in the general population. Objective. The present study was conducted to analyze the characteristics of histologically diagnosed cases of dermatopathic lymphadenopathy at our unit. We also aimed to investigate any association between the clinical features of the patients and the histological findings. Methods. A total of 39 lymph node samples from 39 patients diagnosed with dermatopathic lymphadenopathy were included in this prospective cohort study. Results. Thirty-four (87%) patients had a dermatological disorder. The presence of paracortical eosinophils were significantly higher in patients with dermatological disorders ( P = .001), while the presence of dilated sinuses was significantly more common in patients without a dermatological disorder ( P = .035). The presence of dilated sinuses and medullary histiocytes were significantly more common in patients with lower body surface area involvement of the disease compared to the ones with a higher body surface area ( P = .003, P = .034; respectively). Conclusion. Most of the patients included in the study had one of a broad spectrum of undiagnosed dermatological disorders. The clinical significance of the relation between histological and clinical findings in dermatopathic lymphadenopathy remains to be explained. Dermatopathic lymphadenopathy should always be considered in differential diagnoses of patients with persistent lymph node enlargement even when absolute dermatological disorders are not present. Since various skin disorders may be the cause of lymphadenopathy, performing a full-body examination before lymph node excision might prevent unneccessary procedures.

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Section: Discussionmentioning

confidence: 96%

Correlation Between Clinical and Histological Features of Dermatopathic Lymphadenopathy: Analysis of 39 Lymph Nodes

et al. 2023

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“…In myeloid sarcoma with monocytic differentiation, the myeloid/monocytic antigens are positive, and the S100 protein is negative as compared with metastatic melanoma, in which the melanoma cells are S100 positive with atypical mitosis 4. Other system conditions like syphilis and HIV are also associated with DL 8,9. Skin conditions associated with DL, include pemphigus vulgaris, psoriasis, eczema, neurodermatitis, toxic shock syndrome and atrophia senilis 4.…”

Section: Discussionmentioning

confidence: 99%

Adult onset Still’s disease with dermatopathic lymphadenopathy

Qureshi

AlSheef

Qureshi

et al. 2016

SMJ

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Adult onset Still’s disease (AOSD) is a chronic inflammatory disorder involving multiple systems. The symptoms mimic those of lymphomas, therefore, the diagnosis of lymphoma needs to be excluded prior to establishing the diagnosis of AOSD. Another similar condition is dermatopathic lymphadenopathy (DL). In DL, the histopathological appearance of lymph node biopsy may also mimic AOSD. The DL is associated with several systemic pathologies, such as malignant lymphomas, and rarely AOSD. We present a case of a 43-year-old male presented with 3 months history of fatigue, fever, and lymphadenopathy. Initial work-up satisfactorily met the criteria for diagnosis of AOSD. But considering the well-known association of DL with hematological malignancies, detailed pathological studies were considered, including tumor markers to rule out the possibility of malignancy. The patient was started on steroids and showed remarkable recovery within 2 weeks. Evaluation of malignant lymphomas in a patient with DL is important, in order to diagnose AOSD and rule out hematological malignancy.

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“…Dermatopathic lymphadenitis is often seen in patients with skin diseases, especially mycosis fungoides/Sézary syndrome [ 2 ]. DLN has also been associated with several viral diseases, especially Human Immunodeficiency Virus (HIV) [ 3 ] and Human Papilloma Virus HPV [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Dermatopathic Lymphadenitis Mimicking Breast Cancer with Lymphatic Metastasis: A Case Report and Discussion

2017

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Patient: Female, 56Final Diagnosis: Dermatopathic lymphadenitisSymptoms: LymphadenopathyMedication: —Clinical Procedure: —Specialty: OncologyObjective:Rare co-existance of disease or pathologyBackground:Dermatopathic lymphadenitis is a rare benign lymphatic hyperplasia commonly associated with exfoliative or eczematoid dermatitis. Of interest, this condition can be confused with lymphatic metastasis in adults.Case Report:In this report, we describe the case of a 56-year-old woman diagnosed with left breast invasive ductal carcinoma in remission, who presented with dermatopathic lymphadenitis mimicking breast cancer recurrence.Conclusions:Dermatopathic lymphadenitis is a benign entity that needs to be considered in the differential diagnosis of lymphadenopathy. Pursuing extensive workup in asymptomatic patients with a similar presentation and initial negative tests for malignancy recurrence is not recommended.

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Dermatopathic lymphadenitis in HIV

Cited by 7 publications

References 7 publications

Correlation Between Clinical and Histological Features of Dermatopathic Lymphadenopathy: Analysis of 39 Lymph Nodes

Correlation Between Clinical and Histological Features of Dermatopathic Lymphadenopathy: Analysis of 39 Lymph Nodes

Adult onset Still’s disease with dermatopathic lymphadenopathy

Dermatopathic Lymphadenitis Mimicking Breast Cancer with Lymphatic Metastasis: A Case Report and Discussion

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