Purpose In relation to this research, only a few studies have been carried out around the world. However, in Saudi Arabia, there have been no investigations into this subject. In this sense, the objective of this study was to investigate the physicians' attitudes towards the use of social media for professional purposes in Saudi Arabia. Methods A cross-sectional study was conducted among 235 physicians from different regions of Saudi Arabia. The data were collected by means of a survey. The survey questionnaire was distributed using the WhatsApp application. Descriptive statistics were used to analyze the results. Results The most common social media used by the respondents was Facebook, and the majority of the participants agreed that social media improved their knowledge and skills. However, most of the participants did not interact with patients using these tools, did not feel comfortable conducting an online consultation, and believed that social media affected the choice of the healthcare provider. Similarly, 30.6% of the respondents opined that it is not appropriate to search online information about patients, and 44.3% of them considered that patients would not trust the medical advice if a physician obtained the information from a website. Conclusion The results showed that the majority of the respondents considered that social media improved the knowledge and abilities of physicians. In addition, the respondents reflected that there were ethical issues that must be taken into account when using social media and more than half of them did not interact with their patients employing these tools. The outcomes of this research will help to develop programs directed at the physicians in Saudi Arabia to enhance their knowledge, professional skills, medicine practice, patient-doctor interaction, and handle the risks involved in the use of social media.