Dermatoscope of primary localized cutaneous nodular amyloidosis on hallux nail bed

Cheng, Yong Jian; Li, Yihan; Lim, Kim; Oh, Choon Chiat

doi:10.1016/j.jdcr.2022.07.005

Cited by 4 publications

(4 citation statements)

References 8 publications

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“…Along with a recently published article by Cheng et al [9], the two previously presented cases are the first reports of amyloidomas of the nail unit. In both patients, deposition of amyloid occurred in the distal part of the nail bed, giving rise to a painless firm nodule slowly growing under the nail plate with consequent distal onycholysis.…”

Section: Discussionmentioning

confidence: 70%

Nail Amyloidoma: Two Case Reports of a New Entity

Bonito¹,

Kolivras²,

Saß³

et al. 2023

Skin Appendage Disord

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Introduction: Amyloidosis is a group of diseases characterized by extracellular deposits of abnormal insoluble proteins in different tissues. Amyloidoma is a localized tumoral deposit of amyloid in the absence of systemic amyloidosis, and it has been described in different anatomic sites. We report two cases of amyloidoma in the nail unit and provide insights into this recently described entity. Case Presentation: Both cases presented as an asymptomatic, slowly growing nodule underneath the distal nail bed of a toe with associated onycholysis. Histopathology was characterized in both patients by the presence of deposits of Congo red-positive, homogeneous, amorphous, and eosinophilic material within the dermis and subcutaneous tissue admixed with aggregates of plasma cells. In both cases, an extensive workup excluded systemic amyloidosis. Treatment was based on local excision, and no local recurrence or progression to systemic amyloidosis was observed at 1 year of follow-up. Conclusion: These are the first reports of amyloidomas of the nail unit. The clinical and histopathological presentations parallel those of an amyloidoma affecting the skin. Local excision seems to be an efficient treatment modality, but long-term follow-up is warranted in order to exclude recurrence, an associated marginal B-cell lymphoma, or progression to systemic amyloid L amyloidosis.

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Section: Discussionmentioning

confidence: 70%

Nail Amyloidoma: Two Case Reports of a New Entity

Bonito¹,

Kolivras²,

Saß³

et al. 2023

Skin Appendage Disord

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“…As for the bright white lines, they may be related to a change in the composition or orientation of the collagen. They can be seen more clearly with polarized light [15].…”

Section: Discussionmentioning

confidence: 87%

Localized Cutaneous Nodular Amyloidosis in a Patient with Sjögren’s Syndrome

Llamas‐Molina

Velasco-Amador

Gomar

et al. 2023

IJMS

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Primary localized cutaneous nodular amyloidosis (PLCNA) is included in the primary forms of cutaneous amyloidosis along with macular and lichenoid amyloidosis. It is a rare disease attributed to plasma cell proliferation and deposition of immunoglobulin light chains in the skin. We present the case of a 75-year-old woman with a personal history of Sjogren’s syndrome (SjS), who consulted for asymptomatic yellowish, waxy nodules on the left leg. Dermoscopy of the lesions showed a smooth, structureless, yellowish surface with hemorrhagic areas and few telangiectatic vessels. Histopathology revealed an atrophic epidermis and deposits of amorphous eosinophilic material in the dermis with a positive Congo red stain. The diagnosis of nodular amyloidosis was made. Periodic reevaluation was indicated after the exclusion of systemic amyloidosis. PLCNA is often associated with autoimmune connective tissue diseases, and up to 25% of all PLCNA cases occur in patients with SjS. Therefore, in addition to ruling out systemic amyloidosis, screening for possible underlying SjS should be performed when the diagnosis of PLCNA is confirmed.

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“…disease is estimated to occur in approximately 7% of the cases, [1][2][3][4][5][6] thus its recognition is of key importance to prompt diagnose any possible extra-cutaneous involvement. In this regard, dermoscopy has been shown to highlight some findings that may support PLCNA recognition, thereby facilitating the differential diagnosis with its clinical mimickers, mainly including cutaneous lymphomas and granulomatous dermatoses.…”

mentioning

confidence: 99%

“…In this regard, dermoscopy has been shown to highlight some findings that may support PLCNA recognition, thereby facilitating the differential diagnosis with its clinical mimickers, mainly including cutaneous lymphomas and granulomatous dermatoses. [1][2][3][4][5][6] Here, we present a case of PLCNA with dermoscopic findings, also reviewing existing literature data on this topic and providing a homogeneous terminology according to the standardized dermoscopic criteria for non-neoplastic dermatoses released by the International Dermoscopy Society. 7 A female presented with a 1-year history of asymptomatic pink-brown nodules on the posterior part of her left leg (Figure 1a).…”

mentioning

confidence: 99%

Dermoscopy of Primary Localized Cutaneous Nodular Amyloidosis

Pulgarin,

De Pellegrin,

Stinco

et al. 2024

CCID

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Dermatoscope of primary localized cutaneous nodular amyloidosis on hallux nail bed

Cited by 4 publications

References 8 publications

Nail Amyloidoma: Two Case Reports of a New Entity

Nail Amyloidoma: Two Case Reports of a New Entity

Localized Cutaneous Nodular Amyloidosis in a Patient with Sjögren’s Syndrome

Dermoscopy of Primary Localized Cutaneous Nodular Amyloidosis

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