Dermatoses réactionnelles rares après radiothérapie : une série de cas avec cancer du sein

Dalmasso, C.; Tournier, É.; Lafontan, B. De; Modesto, A.; Chantalat, Élodie; Gladieff, Laurence; Jouve, Eva; Livideanu, C. Bulai; Izar, F.; Sibaud, V.

doi:10.1016/j.canrad.2016.11.004

Cited by 7 publications

(5 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the occurrence of vitiligo after radiotherapy is uncommon and, to our knowledge, there are less than 20 cases reported worldwide 12,14 . The pathophysiology would probably involve the susceptibility of certain melanocytes to apoptosis mediated by oxidative stress, and to free radicals generated by irradiation [11][12][13][14] , although most cases report lesions in the entire portion affected by radiotherapy 11,14 , and not only in scar topography. In addition, the patients described in this series had good tolerance to radiotherapy and minimal inflammatory effect on the breasts, which reduced the possibility of skin lesions secondary to radiotherapy.…”

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

“…Radiotherapy is also associated with several clinical manifestations, as well as early and late skin toxicity 11,12 , including the occurrence of the phenomenon in the absence of previous surgical procedures 13 . However, the occurrence of vitiligo after radiotherapy is uncommon and, to our knowledge, there are less than 20 cases reported worldwide 12,14 . The pathophysiology would probably involve the susceptibility of certain melanocytes to apoptosis mediated by oxidative stress, and to free radicals generated by irradiation [11][12][13][14] , although most cases report lesions in the entire portion affected by radiotherapy 11,14 , and not only in scar topography.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Vitiligo as a Köebner phenomenon after oncoplastic breast surgery

Paulinelli¹,

Soares

Seba

2020

Mastology

View full text Add to dashboard Cite

The Köebner phenomenon is characterized by the appearance of several types of dermatological lesions after traumatic stimulation. The triggering of this phenomenon after breast surgery is uncommon and usually associated with psoriatic lesions. The aim of this study was to describe two cases of vitiligo as the initial manifestation of Köebner phenomenon after breast oncoplastic surgery. Case 1: female, 41 years old, no history of dermatological pathologies, presenting with tubular carcinoma in the right breast. Quadrantectomy and sentinel lymph node biopsy were performed, followed by reconstruction with mammoplasty. Later, the patient started on tamoxifen and underwent radiotherapy, without complications. Thirty days after treatment, the patient presented progressive depigmentation of the areola-papillary complex. Topical treatment was started with dermatological ointment tacrolimus monohydrate and, after one year, the condition was completely resolved. Case 2: 52-yearold woman with previous history of vitiligo on the face, with complete clinical response after dermatological treatment. She was diagnosed with ductal carcinoma in situ on the left breast and underwent quadrantectomy, by means of mammoplasty using the round block technique. Afterwards, she underwent radiotherapy and started tamoxifen. Four years after the surgery, she developed dyschromia in the ipsilateral periareolar region and was diagnosed with vitiligo. Local dermopigmentation was offered, but the patient opted for an expectant conduct and clinical follow-up. To our knowledge, this is the first description of Köebner phenomenon after breast oncoplastic surgery. In these cases, the therapeutic approach must be multidisciplinary and count on the assessment of multiple clinical and individual parameters.

show abstract

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Vitiligo as a Köebner phenomenon after oncoplastic breast surgery

Paulinelli¹,

Soares

Seba

2020

Mastology

View full text Add to dashboard Cite

show abstract

“…The reference lists of retrieved articles were manually scrutinized to identify potentially relevant articles. Our search revealed that mastocytosis associated with a radiotherapy field after breast surgery, has only been reported in six cases in the literature [ 5 – 9 ]. All occurred in female patients who had breast cancer and were treated with surgery and adjuvant radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

Radiotherapy for breast cancer associated with a cutaneous presentation of systemic mastocytosis—a case report and literature review

Easwaralingam

Cheung

et al. 2018

Journal of Surgical Case Reports

View full text Add to dashboard Cite

Ionizing radiation therapy is a common adjuvant therapy for individuals undergoing surgery for breast cancer. There are many well-recognized acute and chronic cutaneous reactions that can vary in severity, course and duration. We present a rare cutaneous manifestation of systemic mastocystosis, in a 59-year-old female who underwent adjuvant radiotherapy following local excision of ductal carcinoma in situ.

show abstract

“…Needle acupuncture [130] Radiotherapy [131][132][133][134][135] Cupping therapy [136,137] Hirudotherapy [138] Specific Immunotherapy [139] Pulsed dye laser [140] Laser hair removal [141,142] Platelet-rich plasma injection [143] Subcutaneous Methotrexate/ Insulin Injection [144][145][146] Purified protein derivative (PPD)/ Mantoux test [31,147,148] Ayurveda [149] Colostomy Bag [150] Hair transplantation/ skin grafting [151,152] Mohs micrographic surgery [111] Electrocardiogram electrode negative pressure suction [153] Secondary to other diseases…”

Section: Vaccination [129]mentioning

confidence: 99%

Characteristics and pathogenesis of Koebner phenomenon

Zhang

Jiang

et al. 2022

Experimental Dermatology

View full text Add to dashboard Cite

The Koebner phenomenon, also known as isomorphic reaction, refers to the development of secondary lesions with the same clinical manifestations and histopathological characteristics as the primary lesions in normal skin after trauma or other stimuli. The triggering factors of Koebner phenomenon include physical trauma, chemical stimulation, mechanical stress, iatrogenic stimulation and pathogenic infection. Vitiligo, psoriasis and lichen planus are considered true Koebner phenomenon. Recent studies have shown that immunological disorders, oxidative stress, defective melanocyte adhesion and growth factor deficiency are the main pathological mechanisms of vitiligo Koebner phenomenon. In psoriasis, triggers may drive skin inflammation to induce a psoriatic phenotype through multiple signalling pathways and thereby cause Koebner phenomenon in susceptible individuals. Significantly, keratinocytes mediate the occurrence of Koebner phenomenon in psoriasis through mechano‐induced signalling pathways after sensing mechanical signals and explains the high frequency of psoriasis lesions on the extensor side of the elbow and knee joints. On the contrary, TRPA1‐driven mechano‐transduction, autoimmunity and actinic damage are the underlying mechanisms of Koebner phenomenon in lichen planus. In this review, we have summarized the current understanding of the characteristics and pathogenesis of Koebner phenomenon.

show abstract

Dermatoses réactionnelles rares après radiothérapie : une série de cas avec cancer du sein

Cited by 7 publications

References 26 publications

Vitiligo as a Köebner phenomenon after oncoplastic breast surgery

Vitiligo as a Köebner phenomenon after oncoplastic breast surgery

Radiotherapy for breast cancer associated with a cutaneous presentation of systemic mastocytosis—a case report and literature review

Characteristics and pathogenesis of Koebner phenomenon

Contact Info

Product

Resources

About