Dermatosis ampollosa hemorrágica a distancia; dos nuevos casos por enoxaparina y revisión de la literatura

Villanueva, C.A.; Nájera, Laura; Espinosa, Patricia; Borbujo, J.

doi:10.1016/j.ad.2011.06.012

Cited by 26 publications

(7 citation statements)

References 6 publications

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“…In most case reports, the authors reported that they used an alternative anticoagulant such as Warfarin. It has been reported that unfractionated heparin could be used in enoxaparin-induced bullous hemorrhagic dermatosis [12] and even that enoxaparin could be readministered without recurrence [11]. However, in this case, the bullous hemorrhagic lesions recurred after the readministration of enoxaparin.…”

Section: Discussionmentioning

confidence: 81%

“…Cases of hemorrhagic bullous dermatosis due to dalteparin, tinzaparin, and unfractionated heparin have been reported [711]. There could be cross-reactivity among low-molecular-weight heparin or unfractionated heparin but it is not clear.…”

Section: Discussionmentioning

confidence: 99%

“…Blood-filled intraepidermal or subcorneal vesicles and blisters with no signs of vasculitis or capillary thrombosis have been reported [11]. Infiltration of inflammatory cells such as eosinophil or neutrophil was not definite, and direct immunofluorescence test result is usually negative [8910].…”

Section: Discussionmentioning

confidence: 99%

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Bullous hemorrhagic dermatosis due to enoxaparin use in a bullous pemphigoid patient

Shim

Chung

Kim

et al. 2017

Asia Pacific Allergy

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Adverse reactions of subcutaneous low molecular weight heparin or unfractionated heparin could be complications by bleeding, heparin-induced thrombocytopenia, drug-induced liver injury, osteoporosis, and cutaneous reactions. Heparin-induced skin lesions vary from allergic reactions like erythema, urticaria, eczema to intradermal microvascular thrombosis associated with heparin-induced thrombocytopenia. There is a rare cutaneous complication, called bullous hemorrhagic dermatosis. We experienced this rare case of the cutaneous complication caused by enoxaparin. Several tense bullous hemorrhagic lesions occurred after 3 days of enoxaparin in a known bullous pemphigoid patient who had aortic valve replacement surgery with a mechanical prosthesis. The bullous hemorrhagic lesions were regressed after the discontinuation of enoxaparin but recurred after re-administration. The lesions were controlled by the administration of systemic corticosteroid and alternative anticoagulant. To date, less than 20 cases have been reported worldwide. This is the first case of bullous hemorrhagic dermatosis induced by enoxaparin, a low-molecular-weight heparin in Korea. This is also the first case of bullous hemorrhagic dermatosis in a known bullous pemphigoid patient.

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

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Bullous hemorrhagic dermatosis due to enoxaparin use in a bullous pemphigoid patient

Shim

Chung

Kim

et al. 2017

Asia Pacific Allergy

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“…[2] reported two cases of hemorrhagic bullous dermatosis after 8 and 10 days of starting on enoxaparin. The lesions resolved without sequelae in 2 to 3 weeks in spite of continuing with treatment.…”

Section: Discussionmentioning

confidence: 99%

“…[1] The most common adverse skin effects with these anticoagulants are ecchymoses, skin necrosis, urticaria, angioedema, and eczema. [2]…”

Section: Introductionmentioning

confidence: 99%

Bullous hemorrhagic dermatosis: A case report

Naveen

Rai

2014

Indian J Dermatol

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We present a case of hemorrhagic bullous dermatosis occurring in areas distant from the site of injection of enoxaparin. A 88 year old woman was admitted for inter trochantric fracture. She was put enoxaparin 60mg subcutaneous 12 hrly for deep vein thrombosis. After 5 days she developed huge hemorrhagic bulla on left leg and multiple hemorrhagic bullae at other sites distant from injected site. A diagnosis of Bullous hemorrhagic dermatoses due to enoxaparin was made. Enoxaparin was stopped and started on oral heparin. Lesions started to regress. Only 9 similar cases have been reported throughout world and none from India.

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Anticoagulants

Özkaya¹,

Yazganoğlu²

2014

Adverse Cutaneous Drug Reactions to Cardiovascular Drugs

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Dermatosis ampollosa hemorrágica a distancia; dos nuevos casos por enoxaparina y revisión de la literatura

Cited by 26 publications

References 6 publications

Bullous hemorrhagic dermatosis due to enoxaparin use in a bullous pemphigoid patient

Bullous hemorrhagic dermatosis due to enoxaparin use in a bullous pemphigoid patient

Bullous hemorrhagic dermatosis: A case report

Anticoagulants

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