1986
DOI: 10.1007/bf01982643
|View full text |Cite
|
Sign up to set email alerts
|

Dermatosis in magnesium-deficient hairless rats: Effects of steroidal and non-steroidal anti-inflammatory drugs

Abstract: Dermatosis in magnesium-deficient hairless rats has been described as a reproducible model of skin inflammation. It was therefore felt of interest to search for the effects of various anti-inflammatory compounds on this model. Results showed that 1) Dexamethasone acetate completely abolished the rash, 2) Indomethacin, a Non-Steroidal Anti-Inflammatory Drug (NSAID), inhibitor of the cyclooxygenase pathway was quite inactive, 3) Benoxaprofen, a NSAID inhibitor of both cyclooxygenase and lipoxygenase pathways onl… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

0
14
0

Year Published

1986
1986
2003
2003

Publication Types

Select...
4
1

Relationship

1
4

Authors

Journals

citations
Cited by 7 publications
(14 citation statements)
references
References 4 publications
0
14
0
Order By: Relevance
“…There may be variance in the on compensative ability among the rat strains. In contrast to zinc deficiency dermatitis, which usually involves acral or peri-oral skin (12), magnesium-deficient rats developed the rash mainly on the trunk. Peri-orificial regions, including the eyelids, were the site involved in common involved in both dermatoses.…”
Section: Discussionmentioning
confidence: 84%
See 3 more Smart Citations
“…There may be variance in the on compensative ability among the rat strains. In contrast to zinc deficiency dermatitis, which usually involves acral or peri-oral skin (12), magnesium-deficient rats developed the rash mainly on the trunk. Peri-orificial regions, including the eyelids, were the site involved in common involved in both dermatoses.…”
Section: Discussionmentioning
confidence: 84%
“…As the mechanism of this dermatitis is obscure, great efforts have been made to elucidate the question by employing pharmacological or therapeutic techniques (1,2,10,12). The results of these reports show that anti-HI mepyramine and anti-H, cimetidine alone or in combination do not modify this dermatitis (1).…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…Dermatosis was induced and followed as previously described [3]. Briefly, ninety male hairless rats (Iffa-Credo, France), weighing about 200-250 g were included in these assays.…”
Section: Methodsmentioning
confidence: 99%