Dermofasciectomy : a long term review

Kelly, C.; Varian, J. P. W.

doi:10.1016/s0753-9053(05)80274-1

Cited by 15 publications

(10 citation statements)

References 3 publications

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“…In DD, skin overlying nodular (SON) tissue as well as perinodular fat (PNF) have been shown to be abnormal and it has been suggested that they may have a role in the pathogenesis of DD [10][11][12]. The reduced rate of recurrence after a dermofasciectomy (a surgical procedure that involves excision of the SON and PNF including the nodule and cord en bloc) also demonstrates that the skin and fat in DD may be involved in the disease process [13]. Although the involvement of the skin in DD is not a new concept [10], more understanding of its function in terms of disease progression and recurrence would be most beneficial.…”

Section: Introductionmentioning

confidence: 99%

Identification of Mesenchymal Stem Cells in Perinodular Fat and Skin in Dupuytren's Disease: A Potential Source of Myofibroblasts with Implications for Pathogenesis and Therapy

Iqbal

Manning

Syed

et al. 2012

Stem Cells and Development

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Dupuytren's disease (DD) is a fibroproliferative disorder characterized by aberrant proliferation of myofibroblasts, the source of which remains unknown. Recent studies indicate that circulating and tissue-resident mesenchymal stem cells (MSCs) can differentiate into myofibroblasts. Therefore, the aim of this study was to profile MSCs from phenotypically distinct DD sites including cord, nodule, skin overlying nodule (SON), and perinodular fat (PNF) compared with unaffected internal controls, that is, distant palmar fat (DPF) and transverse palmar fascia (Skoog's fibers) as well as external control carpal tunnel (CT) tissue including skin, fat, and fascia. Freshly isolated primary fibroblasts as well as cells grown up to passage 5 (P5) from DD (n=27) and CT (n=14) samples were analyzed for the presence of established MSC markers CD73, CD90, and CD105 and absence of hematopoietic marker CD34 using fluorescence-activated cell sorting, in-cell quantitative western blotting, immunohistochemistry, and immunocytochemistry. Freshly isolated cells from SON, PNF, and cord biopsies had a higher number of CD34(-)73(+)90(+)105(+) cells compared with Skoog's fibers and CT controls. P3 cells obtained from all DD biopsies compared with CT samples differentiated into osteocytes, adipocytes, and chondrocytes. P3 cord and nodule cells expressed intense α-smooth muscle actin staining compared with skin and fat cells. Stem cell markers including stem cell factor, MSC-homing marker CXCR4, and Wnt/β-catenin downregulator Dkk-1 were all upregulated in SON and PNF compared with CT skin and CT fat, respectively, as shown by real-time quantitative polymerase chain reaction. However, osteogenic marker OSF-1 had a significantly higher expression in the PNF (P=0.002) and cord (P=0.01) compared with the nodule. In conclusion, we have shown the presence of MSCs in specific DD tissue phenotypes compared with internal and external control tissue. These findings provide preliminary support for a potential alternative source of disease myofibroblasts originating from sites such as SON and PNF as opposed to palmar fascia alone.

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Section: Introductionmentioning

confidence: 99%

Identification of Mesenchymal Stem Cells in Perinodular Fat and Skin in Dupuytren's Disease: A Potential Source of Myofibroblasts with Implications for Pathogenesis and Therapy

Iqbal

Manning

Syed

et al. 2012

Stem Cells and Development

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“…[1] Reported recurrence rates vary from 0 to 73% for PF, [12,19,20] 50 to 85% for PNF, [1,14,19,21] and 8 to 47% for dermofasciectomy. [11,22] The reasons these figures vary so largely are the lack of standard definitions for recurrence and the varying follow-up periods.…”

Section: Discussionmentioning

confidence: 99%

“…The majority of patients with recurrent disease after PNA may be treated safely and effectively with a repeat PNA procedure. [15][16][17][18][19][20][21][22][23][24][25] Limitations in this study include the absence of preoperative DASH and VAS scores and the small sample size. Furthermore, initial corrections achieved post procedure were not compared with corrections maintained at the first follow-up visit.…”

Section: 6% 2010mentioning

confidence: 99%

Percutaneous needle aponeurotomy for the treatment of Dupuytren’s contracture

Karakaplan

Ertem

Polat

et al. 2019

Eklem Hastalik Cerrahisi

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Bu çalışmada perkütan iğne aponörotomi tekniği ile tedavi edilen Dupuytren kontraktürü (DK) olan hastaların erken dönem sonuçları sunuldu. Hastalar ve yöntemler: Bu retrospektif çalışmaya Kasım 2011 ve Aralık 2015 tarihleri arasında DK nedeniyle perkütan aponörotomi ile tedavi edilen 28 hasta (20 erkek, 8 kadın; ort. yaş 63 yıl; dağılım, 44-88 yıl) (75 parmak) dahil edildi. Hastalar demografik özellikleri, ek hastalık varlığı, aile öyküsü, ilaç kullanım öyküsü, komplikasyon oranı, nüks gelişimi, ameliyat sonrası hasta memnuniyeti, yeniden ameliyat olma isteği, ameliyat sonrası Kol Omuz ve El Sorunları Anketi ve görsel analog ölçeği skorlarına göre değerlendirildi. Bulgular: Ortalama takip süresi 29 ay (dağılım, 12-60 ay) idi. Ameliyat sonrası memnuniyet anketinde hastaların %92.9'u (n=26) memnun kaldığını ifade etti. Yeniden ameliyat olma isteği anketinde hastaların %82.1'i (n=23) yeniden ameliyatı kabul etti. Komplikasyon oranı %39.3 iken nüks oranı %35.7 idi. Sonuç: Perkütan iğne aponörotomi tekniği DK tedavisi için etkili, basit ve güvenli bir yöntem olabilir.

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“…L'excision de la peau avec la lésion et son remplacement par une greffe cutanée ou partiellement par un lambeau local (latérodigital, intermétacarpien palmaire) semble être seule capable d' éviter ou de diminuer les récidives [10], valant parfois le qualificatif de « pare-feu » à la greffe. Plusieurs études ont montré la réduction [11][12][13], voire l'absence [1,[14][15][16][17][18] de récidive avec dermofasciectomie et greffe de peau. Ces auteurs recommandent d'ailleurs d'utiliser cette technique d'emblée dans les formes agressives [11][12][13] ou secondairement dans les formes récidivantes [12,15,[17][18][19].…”

Section: Discussionunclassified