Dermoid cysts of the ovary with malignant transformation: MR appearance.

Kido, Aki; Togashi, Kaori; Konishi, Ichirou; Kataoka, Milliam L.; Koyama, Takashi; Ueda, Haruhiko; Fujii, Shoich; Konishi, Junji

doi:10.2214/ajr.172.2.9930800

Cited by 153 publications

(113 citation statements)

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“…In terms of imaging study, Kido et al reported that mature cystic teratoma with malignant transformation tends to have a solid component that exhibits an extensive transmural extension and direct invasion of neighboring pelvic organs in the MR appearance, but earlier diagnosis is difficult (15). In our series, while all the 7 advanced cases were correctly Figure 3.…”

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confidence: 49%

“…------------------------------------------------diagnosed as malignant by MR (and CT in some cases), only 2 out of 4 cases and none of 2 cases of stage Ia disease were diagnosed as malignant with MR and CT, respectively. These results suggested that, so far, a CT or MRI is helpful only when characteristic images such as transmural invasion or the spread of malignant tumors become apparent (15). Another report suggested that evaluating the presence or absence of intratumoral blood flow, together with blood flow resistance in tumor vessels using transvaginal color Doppler ultrasound may be more useful in differentiating malignant (SCC) from benign cystic teratomas of the ovary than by measuring serum SCC levels (16).…”

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confidence: 99%

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Malignant transformation of mature cystic teratoma of the ovary including three cases occurring during follow-up period

Yamaguchi

Mandai²,

Fukuhara³

et al. 2008

Oncol Rep

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Abstract. The aim of this study was to seek for factors which lead to the early diagnosis of malignant transformation from mature cystic teratoma. Fourteen patients with malignant transformation from mature cystic teratoma of the ovary were analyzed retrospectively for precise clinicopathology and prognosis. The results demonstrated that although all the patients with stage Ia disease were disease-free, only 2 out of 7 patients were stage Ic to IV and disease-free in the follow-up period. Pre-operative imaging correctly diagnosed tumors as malignant in all stage Ic to IV cases, but only in 2 out of 4 stage Ia cases with magnetic resource and none of the 2 cases with computed tomography, respectively. In malignant cases, elevation of the serum SCC and CEA was observed in 90.9 and 88.9%, respectively. On the other hand, in benign cases, a false positive elevation of the serum SCC and CEA was observed in 23.5 and 14.3%, which turned out to be normal in 40 and 52.9% cases in the repeated study, respectively. In conclusion neither imaging analysis nor tumor markers including SCC and CEA accurately diagnose malignant transformation of mature cystic teratoma in its early stage, suggesting that a combination of diagnostic means is important. In the followup cases, repeated measurement of serum markers proved useful in ruling out false positive cases.

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Section: ------------------------------------------------------------mentioning

confidence: 49%

Section: ------------------------------------------------------------mentioning

confidence: 99%

Malignant transformation of mature cystic teratoma of the ovary including three cases occurring during follow-up period

Yamaguchi

Mandai²,

Fukuhara³

et al. 2008

Oncol Rep

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“…Mature cystic teratomas of the ovary www.journalchiromed.com make up 10% to 25% of ovarian neoplasms. 4 Mature cystic teratomas, the most common germ cell neoplasm, are collections of well-differentiated derivations from at least 2 of 3 germ cell layers: ectoderm (skin, brain), mesoderm (muscle, fat), and endoderm (mucinous or ciliated epithelium). 5 The components of the cyst may include hair, sebum, and teeth.…”

Section: Introductionmentioning

confidence: 99%

“…7 Because of the predominance of skin elements, mature cystic teratomas are also referred to as dermoid cysts. 4 Mature cystic teratomas, in their pure form, are always benign, although they may rarely undergo malignant transformation. The prevalence of mature cystic teratomas undergoing malignant transformation is 1% to 2%, with a subsequent poor prognosis due to the delay in identifying the transformation before metastatic spread.…”

Section: Introductionmentioning

confidence: 99%

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A calcific pelvic mass in a woman with chronic spinal pain: a case of mature cystic teratoma

Kaeser

McDonald²,

Kettner

2011

Journal of Chiropractic Medicine

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Objective: The purpose of this case is to describe findings of a mature cystic teratoma and to further provide differential diagnoses for ovarian pelvic masses and calcifications. Clinical Features: A 27-year-old woman presented to a chiropractic teaching clinic with a chief complaint of chronic multilevel spinal pain. During a full spine radiographic examination, radiopaque densities were incidentally identified in the pelvic bowl visualized through a gonad shield. Follow-up pelvic radiography revealed several radiopacities of uniform density localized in the pelvic bowl. Intervention/Outcomes: Medical (gynecological) consultation led to ultrasonography of the pelvis that revealed a mature cystic teratoma. The patient underwent complete excision of the mass through a laparotomy procedure. The patient continued to receive chiropractic treatment of her original cervical and lumbar spine complaints, further suggesting that the pelvic mass was not a source of her musculoskeletal complaints. Conclusion: This case demonstrates the detection and proper referral of a patient with a calcific mass. The presence of a pelvic mass, suspected of arising from the ovary, requires additional diagnostic imaging and careful clinical correlation.

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