Dermoid Cysts of the Testis

Dockerty, Malcolm B.; Priestley, James T.

doi:10.1016/s0022-5347(17)70726-4

Cited by 82 publications

(57 citation statements)

References 8 publications

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“…Epidermoid cysts were first described in 1942 by Dockerty and Priestly (18). They are uncommon, and are composed of cysts lined by squamous epithelium.…”

Section: Discussionmentioning

confidence: 99%

Interphase Fluorescence In situ Hybridization Analysis of Chromosome 12p Abnormalities Is Useful for Distinguishing Epidermoid Cysts of the Testis from Pure Mature Teratoma

Liu

Zhang²,

MacLennan

et al. 2006

Clinical Cancer Research

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Purpose: The distinction of epidermoid cyst of the testis from teratoma is of critical importance because the former is benign and the latter is a malignant tumor that may have associated metastasis of either teratomatous or non^teratomatous germ cell tumor types. Chromosome 12p abnormalities are seen in the vast majority of testicular germ cell tumors of adults and are present in all histologic subtypes. In this study, we investigated the clinical utility of interphase fluorescence in situ hybridization (FISH) analysis of chromosome 12p abnormalities for distinguishing epidermoid cysts of the testis from pure mature teratoma. Experimental Design: Sixteen testicular epidermoid cysts and 17 testicular teratomas were investigated for isochromosome 12p [i(12p)] and 12p overrepresentation using interphase FISH analysis. Results: Neither i(12p) nor 12p overrepresentation were observed in 16 epidermoid cyst cases, whereas i(12p) was detected in 76% of teratomas and 12p overrepresentation was identified in 29% of teratomas. Overall, 88% of testicular teratomas had chromosome 12p abnormalities. Conclusions: FISH identification of i(12p) and/or 12p overrepresentation in routinely processed surgical specimens is a useful ancillary diagnostic tool in distinguishing testicular epidermoid cysts from teratoma.

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“…Epidermoid cysts were first described in 1942 by Dockerty and Priestly (18). They are uncommon, and are composed of cysts lined by squamous epithelium.…”

Section: Discussionmentioning

confidence: 99%

Interphase Fluorescence In situ Hybridization Analysis of Chromosome 12p Abnormalities Is Useful for Distinguishing Epidermoid Cysts of the Testis from Pure Mature Teratoma

Liu

Zhang²,

MacLennan

et al. 2006

Clinical Cancer Research

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“…6 It was finally in 1969 when Price et al described the histomorphological features of this rare tumour in a series of 69 cases. Thus, established criteria for a conclusive diagnosis of testicular epidermoid cyst are (i) the lesion must be located within the testicular parenchyma; (ii) the luminal contents of the cyst should comprise of keratinized debris; (iii) dermal appendages or teratoid elements should not exist within the cystic lesion; (iv) no scars should be present in the parenchyma adjacent to the epidermoid cyst.…”

Section: Discussionmentioning

confidence: 99%

Intra-testicular epidermoid cyst: a rare case report with clinico-radiological dilemma

et al. 2017

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Intra-testicular epidermoid cyst of testis is a benign tumour and accounts for 1-2% of all testicular neoplasms. It is a benign lesion, and should be distinguished from dermoid cyst or teratoma, which have a considerable malignant potential. We describe a rare case of testicular epidermoid cyst in an elderly male presenting with gradually increasing testicular mass since 8 months. Local examination revealed a non-tender, irregular, hard mass in the right testis. All routine laboratory investigations along with tumour markers were within normal limits. Ultrasound showed features of a testicular neoplasm following which orchidectomy was performed. Grossly, cut surface of testis showed a cyst measuring 4x2x1cm and microscopic examination revealed features of an epidermoid cyst. Extesive sampling excluded the possibility of a teratomatous focus. This case is described owing to the rarity of this neoplasm and the unusual clinico-radiological presentation. The pre-operative diagnosis of this tumour can be made if characteristic sonographic and MRI findings are obtained in the absence of which these masquerade neoplastic lesions. Histopathological examination thus is vital for a decisive diagnosis.

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“…Epidermoid cysts of the testes was first reported by Dockerty and Priestly in 1942 [5], To date about 300 instances of occurences are reported in medical literature [3]. The lesion commonly presents in the second to fourth decades of life as a discreet nodular lesion within the testis, which enlarges slowly and painlessly.…”

Section: Discussionmentioning

confidence: 99%

“…The consensus today favours testicular conservation. Exploration of the testis is carried out by the inguinal route and the decision to sacrifice the testis is reserved pending frozen section histopathology confirming malignancy [1][2][3][4][5]8,9]. It is important on frozen section to differentiate the lesion from mature teratomas and dermoid cysts which are to be treated by an inguinal orchidectomy.…”

Section: Discussionmentioning

confidence: 99%