Dermoscopic Aspects of Cutaneous Adverse Drug Reactions

Rossi, Gabriela; Cartell, André; Bakos, Renato Marchiori

doi:10.5826/dpc.1101a136

“…The dermoscopic features described for DRESS by Rossi et al include erythema, scaling, purpuric dots, and black dots or necrotic areas. [ 21 ] Similarly, the findings in our patient were purpuric dots and black structureless areas (necrotic keratinocytes on histology) with scant white scaling over an dull erythematous to brownish background [ Figure 4c ]. The diagnosis was confirmed histopathologically, which showed parakeratosis, acanthosis, spongiosis, and predominantly lymphocytic dermal inflammatory infiltrate and focal interface dermatitis with apoptotic keratinocytes.…”

Section: Discussionsupporting

confidence: 69%

Utility of Dermoscopy in the Diagnosis of Erythroderma: A Cross-Sectional Study

Batra,

Gulati,

Sarangal

et al. 2023

Indian Dermatology Online Journal

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Background: It is difficult to diagnose the underlying cause of erythroderma on mere clinical presentation. The role of dermoscopy in diagnosing erythroderma secondary to various etiologies is evolving. Aim and Objectives: This study aimed to observe the dermoscopic features of erythroderma secondary to different cutaneous disorders and compare them with clinical features and histopathology. Materials and Methods: Twenty-nine consecutive patients of erythroderma were enrolled in the study. Dermoscopy was performed on every case using a Heine Delta II Dermatoscope with 10x magnification in polarized mode. A histopathological examination was conducted to confirm the diagnosis. Results: Eight patients were diagnosed with psoriasis, five with endogenous eczema, four with pityriasis rubra pilaris (PRP), three with pustular psoriasis, two with drug rash secondary to antitubercular therapy, two with dermatophytic infection, one patient each of atopic dermatitis, crusted scabies, pemphigus foliaceous, drug reaction with eosinophilia and systemic symptoms, and mycosis fungoides. Characteristic dermoscopic features were observed in erythroderma due to psoriasis, PRP, pustular psoriasis, endogenous eczema, scabies, and dermatophytosis. Differentiation of other disorders based on dermoscopy alone was difficult, and clinico-histopathological correlation was crucial to reach a diagnosis. Conclusion: Dermoscopic features of classical patterns of skin disorders are preserved even in the corresponding erythrodermic or unstable stage. Dermoscopic features of erythroderma secondary to psoriasis, pustular psoriasis, PRP, endogenous eczema, scabies, and dermatophytosis are clearly differentiating, whereas the dermoscopic features in other causes of erythroderma are overlapping. Thus, dermoscopy can be a good screening tool in the clinical assessment of erythroderma.

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“…Fiszenson-Albala et al, (2003) [99] also mentioned a high MPR frequency of 57%. Several others mentioned rates >40.0% [10,77,81,86,91,102] (Table 2). Two of the papers mentioned >50.0% cADRs as DIU [91,97].…”

Section: Juniper Online Journal Of Dermatology and Cosmeticsmentioning

confidence: 99%

Untitled

2023

JOJDC

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Medication-related harm or adverse drug reaction is a great global health concern today. They are frequent and, most often, devastating. With the rising incidences of drug-related adverse outcomes, it is imperative that clinicians have the knowledge and understanding of these occurrences to prevent, diagnose, and manage them properly. Skin is a very commonly affected organ system, and incidences of cutaneous adverse drug reactions are between 1-5% depending on the geographic location. Up to 60% or more of all adverse drug reactions may represent cutaneous reactions. These may fall into either of the dose-dependent or dose-independent categories. Being the most prescribed and utilized drug group, antibiotics have been implicated as one of the major drug groups causing cutaneous drug reactions. There is ample evidence that antibiotics cause severe and non-severe cutaneous adverse drug reactions. A review of the present literature was done using MEDLINE/PubMed, Google Scholar, and other search engines to gather evidence to find how extensive the problem is and how much the burden is. Which will enlighten clinicians from all backgrounds and medical students and help them deal with cutaneous adverse drug reactions more prudently.

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“…Fiszenson-Albala et al, (2003) [99] also mentioned a high MPR frequency of 57%. Several others mentioned rates >40.0% [10,77,81,86,91,102] (Table 2). Two of the papers mentioned >50.0% cADRs as DIU [91,97].…”

Section: Juniper Online Journal Of Dermatology and Cosmeticsmentioning

confidence: 99%

Cutaneous Adverse Drug Reactions to Antibiotics: How Much is the Extent of the Problem?

Uddin Umar

2023

JOJDC

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Medication-related harm or adverse drug reaction is a great global health concern today. They are frequent and, most often, devastating. With the rising incidences of drug-related adverse outcomes, it is imperative that clinicians have the knowledge and understanding of these occurrences to prevent, diagnose, and manage them properly. Skin is a very commonly affected organ system, and incidences of cutaneous adverse drug reactions are between 1-5% depending on the geographic location. Up to 60% or more of all adverse drug reactions may represent cutaneous reactions. These may fall into either of the dose-dependent or dose-independent categories. Being the most prescribed and utilized drug group, antibiotics have been implicated as one of the major drug groups causing cutaneous drug reactions. There is ample evidence that antibiotics cause severe and non-severe cutaneous adverse drug reactions. A review of the present literature was done using MEDLINE/PubMed, Google Scholar, and other search engines to gather evidence to find how extensive the problem is and how much the burden is. Which will enlighten clinicians from all backgrounds and medical students and help them deal with cutaneous adverse drug reactions more prudently

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Dermoscopic Aspects of Cutaneous Adverse Drug Reactions

Cited by 6 publications

References 43 publications

Utility of Dermoscopy in the Diagnosis of Erythroderma: A Cross-Sectional Study

Utility of Dermoscopy in the Diagnosis of Erythroderma: A Cross-Sectional Study

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Cutaneous Adverse Drug Reactions to Antibiotics: How Much is the Extent of the Problem?

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