e25 2. Which of the following is TRUE regarding the findings from the study by Halse et al. (2019)? a. Lentigo maligna (LM) pretreatment biopsies showed a statistically significant difference in immune cell subset densities between the responders and non-responders to imiquimod treatment.b. In pretreatment biopsies, the area of the dermis occupied by PD-L1 positive cells was significantly increased in responders to imiquimod as compared with non-responders.c. Posttreatment biopsies from responders and nonresponders had the same expression of genes involved in innate immunity.d. The most predictive baseline genes for response to imiquimod were CD70 and PRAME.e. Within responders to imiquimod therapy, posttreatment biopsies showed upregulation in the signaling pathways affecting leukocyte adhesion.3. After treatment with imiquimod, which of the following was detected in those who responded to treatment? a. Increased production of IFN-1 by plasmacytoid dendritic cells b. Increased expression of BCL-2 anti-apoptotic protein c. Increased expression of CD28 T-cell receptor d. Decreased expression in CTLA-4 costimulatory protein e. Decreased expression of IFN-inducible protein 27 (IFI27) See following pages for detailed answers.