Dermoscopic features of cutaneous post-transplant lymphoproliferative disorder in a renal transplant recipient

Wang, Hua Xian Elizabeth; Tang, Phua Hwee; Oh, Choon Chiat

doi:10.1016/j.jdcr.2022.06.036

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2023

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“…Cutaneous involvement occurs in only 5% of PTLD cases, with most cases being monomorphic (more frequently B-cell than T-cell). 14,[23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] Although the onset with cutaneous involvement is considered a favorable factor, the prognosis of these cases is reserved, with a significant percentage of them ending in death.…”

Section: Discussionmentioning

confidence: 99%

Post-Transplant Lymphoproliferative Disorder, Monomorphic Type, in a Kidney Transplant Patient After Administration of Anti-Influenza Vaccine

Fernandez-Flores,

Nieto Rodriguez,

Fernandez-Parrado

et al. 2023

The American Journal of Dermatopathology

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Post-transplant lymphoproliferative disorders (PTLD) are rare complications in solid organ transplant patients. Their pathogenesis is largely unknown and closely linked to low immunity, which allows uncontrolled lymphocyte proliferation. Although transplant patients receive annual influenza vaccination as a preventive protocol, we have not found any cases where the flu vaccine triggered a PTLD. We present the case of a 49-year-old female kidney transplant recipient who developed an Epstein–Barr virus-negative PTLD, CD30+ anaplastic monomorphic type, ALK-, which presented the day after a single dose of anti-influenza vaccine. The initial clinical presentation was subcutaneous, but imaging studies revealed multiorgan involvement.

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