Dermoscopy and dermatopathology correlates of cutaneous neoplasms

Yélamos, Oriol; Braun, Ralph; Liopyris, Konstantinos; Wolner, Zachary; Kerl, Katrin; Gerami, Pedram; Marghoob, Ashfaq A.

doi:10.1016/j.jaad.2018.07.073

Cited by 74 publications

(136 citation statements)

References 72 publications

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“…Histopathologically, reticular naevi are benign melanocytic proliferations with pigmented, thin and elongated rete ridges. The network of rete ridges is expected to correspond to the reticular pattern from dermoscopy . In our study, the reconstructed 2D top‐down view images, at the depth of the rete ridge, unveiled a clear regular network, forming cobwebs in Naevus1–3 (Fig.…”

supporting

confidence: 62%

“…A considerable number of studies have reported that these structures correspond with their specific histopathological findings. These dermatoscopic–histological correlations have usually been analysed with two‐dimensional (2D) vertical pathological images . Although these clearly show the correlation, it is difficult for the novice to imagine from the top‐down horizontal view obtained from dermoscopy, the vertical view obtained from histopathology.…”

mentioning

confidence: 99%

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Digitally reconstructed top‐down view images provide intuitive understanding of the correlation between dermoscopy and histopathology: a good educational tool

et al. 2019

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supporting

confidence: 62%

mentioning

confidence: 99%

Digitally reconstructed top‐down view images provide intuitive understanding of the correlation between dermoscopy and histopathology: a good educational tool

et al. 2019

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“…Currently, several non-invasive techniques, such as dermoscopy, high frequency ultrasound, and reflectance confocal microscopy, are used to identify the BCC subtype and support the treatment decision. However, histopathology remains the gold standard for BCC subtyping [5][6][7][8]. A skin biopsy is usually the technique performed for this purpose.…”

Section: Introductionmentioning

confidence: 99%

Use of Cytology in the Diagnosis of Basal Cell Carcinoma Subtypes

Pasquali

Segurado‐Miravalles²,

Castillo

et al. 2020

JCM

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Background: Basal cell carcinoma (BCC) is the most common skin cancer in the white population. Nonsurgical treatments are first-line alternatives in superficial BCC (sBCC); therefore, differentiating between sBCC and non-sBCC is of major relevance for the clinician. Scraping cytology possesses several advantages, such as an earlier diagnosis and scarring absence, in comparison to a biopsy. Nevertheless, previous studies reported difficulties in differentiating the different BCC subtypes. The objective of this study was to determine the capability and accuracy of scraping cytology to differentiate between sBCC and non-sBCC. Methods: In this retrospective study, cytological samples of histologically confirmed BCC were examined. Select cytological features were correlated to BCC subtypes (sBCC or non-sBCC). Results: A total of 84 BCC samples were included (29 sBCC; 55 non-sBCC). An inverse correlation between the diagnosis of sBCC and the presence of mucin, dehiscence, and grade of atypia in the basal cells was observed. The presence of medium and large basal cell clusters correlated directly to a sBCC diagnosis. The presence of clear cells is strongly associated with sBCC. Therefore, Conclusion: Scraping cytology is reliable in differentiating sBCC from other BCC subtypes.

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“…Dermoscopy is a noninvasive handheld tool that is equipped with a magnification lens (usually 10×) and a polarized and/or nonpolarized light source that allows visualization of structures typically invisible to the naked eye. These dermoscopic structures provide clues to the diagnosis of various cutaneous tumors and other cutaneous diseases . Dermoscopy has been used as a tool to narrow the differential diagnosis of amelanotic tumors with good reliance; however, PCL have rarely to never been included in these studies.…”

Section: Introductionmentioning

confidence: 99%

Dermoscopy of primary cutaneous B‐ and T‐cell lymphomas and pseudolymphomas presenting as solitary nodules and tumors: a case‐control study with histopathologic correlation

et al. 2019

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Background Primary cutaneous lymphomas (PCLs) and pseudolymphomas presenting as single pink-red nodules/tumors are highly unspecific and include a wide differential diagnosis.Objective To describe the dermoscopic characteristics of PCL/pseudolymphoma. MethodsIn this retrospective, case-control study, we evaluated the dermoscopic features of patients with solitary PCL/pseudolymphoma tumors and compared them to a control group of non-lymphomatous, nonpigmented, solitary tumors (e.g., basal cell carcinoma, amelanotic melanoma, etc). ResultsWe included 14 patients with PCL/pseudolymphomas and 35 controls. T-cell and B-cell lymphoma proportions were 28.6% (n = 4) and 71.4% (n = 10), respectively.Compared to controls, most lymphomas presented dermoscopically with orange color (71.4% vs. 14.2%, P < 0.001), follicular plugs (85% vs. 2.8%, P < 0.001), and as organized lesions (85% vs. 31.4%, P = 0.001). Coexistence of orange color and follicular plugs had an odds ratio (OR) of 2.8 (P < 0.001), highly suggestive of PCL. The kappa index for independent observers was 0.66, 0.49, 0.43 for orange background, follicular plugs, and organized lesion, respectively. Histopathologic correlation was performed in six PCL cases and showed dense diffuse and perifollicular lymphocytic infiltrate in all cases and keratin plugs in five of six cases, possibly correlating with the orange color and the follicular plugs, respectively.Conclusion Primary cutaneous lymphomas/pseudolymphomas present with characteristic dermoscopic findings irrespective of immunohistochemical subtype.

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Dermoscopy and dermatopathology correlates of cutaneous neoplasms

Cited by 74 publications

References 72 publications

Digitally reconstructed top‐down view images provide intuitive understanding of the correlation between dermoscopy and histopathology: a good educational tool

Digitally reconstructed top‐down view images provide intuitive understanding of the correlation between dermoscopy and histopathology: a good educational tool

Use of Cytology in the Diagnosis of Basal Cell Carcinoma Subtypes

Dermoscopy of primary cutaneous B‐ and T‐cell lymphomas and pseudolymphomas presenting as solitary nodules and tumors: a case‐control study with histopathologic correlation

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