Dermoscopy and reflectance confocal microscopy of Kaposi's sarcoma: an overview

Villani, Alessia; Scalvenzi, Massimiliano; Cinelli, Eleonora; Fabbrocini, Gabriella; Stefani, Alessandro

doi:10.1111/jdv.17831

Cited by 4 publications

(8 citation statements)

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“…Dermoscopic findings of VLs were evaluated according to patterns and algorithms adopted in literature 1,2,12–17 …”

Section: Methodsmentioning

confidence: 99%

“…5 Dermoscopic findings of VLs were evaluated according to patterns and algorithms adopted in literature. 1,2,[12][13][14][15][16][17] Line-field confocal optical coherence tomography criteria were defined based on previously described OCT and RCM-based criteria. 3,4,12,15,16,[18][19][20] Additional LC-OCT criteria were defined based on the expert opinion of the authors.…”

Section: Ater I a L S A N D M Ethodsmentioning

confidence: 99%

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Line‐field confocal optical coherence tomography of cutaneous vascular lesions: Morphological assessment and histopathological correlations

Cappilli

Suppa

Ricci

et al. 2023

Acad Dermatol Venereol

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Background Cutaneous vascular lesions (VLs) are benign or malignant processes involving blood and/or lymphatic vessels, usually readily diagnosed with dermoscopy. However, cases showing unclear clinical/dermoscopic findings may require further investigations. Line‐field confocal optical coherence tomography (LC‐OCT) is a new, non‐invasive imaging technique displaying high resolution and deep penetration. The aim of this study was to describe the LC‐OCT features of the most common benign and malignant VLs and to correlate them with histopathological substrates. Methods Clinical, dermoscopic, LC‐OCT and histopathological images of VLs were retrospectively collected. Detailed LC‐OCT description and histopathological correlations were produced for different types of VLs. Results The study included 71 VLs belonging to 50 caucasian patients [31 (62%) females; median age 56.8 (30–83) years] study lesions included 25 cherry haemangiomas, 15 angiokeratomas, 10 thrombosed haemangiomas, six pyogenic granulomas, five venous lakes, four targetoid haemosiderotic haemangiomas, four Kaposi's sarcomas and two extraungual glomus tumours. LC‐OCT detected increased dermal vascularity, assuming different size and shape according to the particular type of VLs. LC‐OCT criteria correlated well to established histopathologic findings. Conclusion The results of our preliminary observations indicate that in vivo evaluation with LC‐OCT may provide practical clues for the identification of the vascular nature of a lesion and its differential diagnosis.

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“…Dermoscopic findings of VLs were evaluated according to patterns and algorithms adopted in literature 1,2,12–17 …”

Section: Methodsmentioning

confidence: 99%

Section: Ater I a L S A N D M Ethodsmentioning

confidence: 99%

Line‐field confocal optical coherence tomography of cutaneous vascular lesions: Morphological assessment and histopathological correlations

Cappilli

Suppa

Ricci

et al. 2023

Acad Dermatol Venereol

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“…Patients affected by classic KS present multiple pink to red‐purple‐colored lesions, varying from a patch, a nodule or a plaque, often localized on the distal lower extremities 1,2 . Although, in the last decade, the use of reflectance confocal microscopy (RCM) as diagnostic tool has been studied in many dermatological diseases, including inflammatory dermatosis, benign and malignant neoplasms, as well as in cosmetic dermatology, 3–5 to date, there are few data regarding the use of RCM in mucocutaneous KS 6 . In literature there is only one study describing reflectance confocal microscopy features of KS lesions and their correlation with histopathological examination 7…”

Section: Introductionmentioning

confidence: 99%

“…1,2 Although, in the last decade, the use of reflectance confocal microscopy (RCM) as diagnostic tool has been studied in many dermatological diseases, including inflammatory dermatosis, benign and malignant neoplasms, as well as in cosmetic dermatology, [3][4][5] to date, there are few data regarding the use of RCM in mucocutaneous KS. 6 In literature there is only one study describing reflectance confocal microscopy features of KS lesions and their correlation with histopathological examination. 7 Although many therapeutic strategies from systemic to local treatment are available for KS, the correct treatment should be tailored according to patients' characteristics.…”

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confidence: 99%

Reflectance confocal microscopy for Kaposi's sarcoma treatment monitoring after intralesional vincristine chemotherapy

Villani

Fabbrocini

Scalvenzi

2022

Dermatologic Therapy

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Kaposi's sarcoma (KS) is a multifocal systemic disease, originating from endothelial cells mainly affecting elderly men. Intralesional chemotherapy with vinblastine or vincristine is an effective and well‐tolerated treatment in patients presenting single nodules on the skin. Despite reflectance confocal microscopy represents a useful diagnostic method for many dermatological diseases, to date, there are few data regarding the use of RCM in mucocutaneous KS. Objective of this study was to evaluate the use of RCM for therapeutic follow‐up in KS patients treated with intralesional vincristine. An observational retrospective study involving patients with a histological diagnosis of classic KS was conducted. All patients were treated with intralesional vincristine; reflectance confocal microscopy images were taken for each patient at baseline (T0) and 1 month after vincristine injection. Four male patients with a median age of 76.8 years were included in the study and four nodules (one for each patient) were evaluated with RCM examination before and after vincristine injections. At 1 month from intralesional vincristine treatment, therapeutic response was confirmed at RCM examination; a reduction of inflammatory cell at the stratum spinosum level in all evaluated lesions was observed; at papillary dermis levels, black luminal structures were decreased in diameter and superficial linear canalicular structures were not represented. Aggregates of inflammatory cells and of hemosiderin deposition, at the dermal level, were reduced in number. Reflectance confocal microscopy showed to be a promising method to evaluate vincristine therapeutic response in patients with KS; further studies evaluating RCM use in KS patients in order to monitor treatment efficacy are still required.

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“…Reflectance confocal microscopy (RCM) is a diagnostic method that allows non-invasive and real-time evaluation of the most superficial layers of skin and mucosa up to the reticular dermis with a quasi-histopathologically resolution. 3,4 A 75-year-old male patient presented to our outpatient clinic for KS with 1 month history of a single purplish nodule appeared on the third toe of the right foot associated with reddish plaques on tongue and glans (Figure 1a,b). Incisional biopsy was performed on the foot's nodule and histopathological examination revealed the presence in the dermis of atypical spindle cells positive for CD34+ with plurifocal positivity for HHV-8 on immunohistochemistry.…”

mentioning

confidence: 99%

Kaposi's sarcoma on oral and genital mucosa: In vivo reflectance confocal microscopy features

Cillo

Patrì

Fabbrocini

et al. 2022

Acad Dermatol Venereol

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Dermoscopy and reflectance confocal microscopy of Kaposi's sarcoma: an overview

Cited by 4 publications

References 9 publications

Line‐field confocal optical coherence tomography of cutaneous vascular lesions: Morphological assessment and histopathological correlations

Line‐field confocal optical coherence tomography of cutaneous vascular lesions: Morphological assessment and histopathological correlations

Reflectance confocal microscopy for Kaposi's sarcoma treatment monitoring after intralesional vincristine chemotherapy

Kaposi's sarcoma on oral and genital mucosa: In vivo reflectance confocal microscopy features

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