Dermoscopy of Disseminated Superficial Actinic Porokeratosis

Nicola, Andrea; Magliano, Julio

doi:10.1016/j.ad.2015.09.025

Cited by 28 publications

(21 citation statements)

References 11 publications

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“…[1] In the present study, the dermoscopic image of DSAP is similar to those that have been previously documented. Moreover, the dermoscopic images of PM and facial PK are similar to that of DSAP.…”

supporting

confidence: 86%

“…Dermoscopic images of PK show an obvious annular margin with scales and an atrophied center. [ 1 ] Wood's lamp pictures of PK present a diamond necklace-like structure. [ 2 ] Gene mutations in mevalonate pathway enzymes, such as mevalonate kinase ( MVK ), phosphomevalonate kinase ( PMVK ), mevalonate decarboxylase ( MVD ), and farnesyl diphosphate synthase ( FDPS ), may be involved in the pathogenesis of PK.…”

mentioning

confidence: 99%

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Dermoscopic Features and Gene Mutation in the Mevalonate Pathway of Five Sporadic Patients with Porokeratosis

Sun

Chen

Zhu

et al. 2017

Chinese Medical Journal

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supporting

confidence: 86%

mentioning

confidence: 99%

Dermoscopic Features and Gene Mutation in the Mevalonate Pathway of Five Sporadic Patients with Porokeratosis

Sun

Chen

Zhu

et al. 2017

Chinese Medical Journal

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“…Minor differences have been reported in the Mibelli and diffuse superficial actinic variant. [ 1 2 ]…”

mentioning

confidence: 99%

Dermoscopy of porokeratosis of mibelli

Jha

Sonthalia²,

Lallas

2017

Indian Dermatol Online J

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“…Moreover, hypoxia might stimulate the transcription of the VEGF gene, resulting in increased angiogenesis and proliferation in the epidermis [ 27 ]. Of note, irregular vessels are observed in PK lesions through dermoscopic examination [ 28 – 30 ], which are usually neglected by naked eyes. In addition, one case of primary cardiac amyloidosis associated with PK was reported in the literature [ 31 ] .…”

Section: Discussionmentioning

confidence: 99%

Mvda is required for zebrafish early development

Wong

Huang

et al. 2021

Biol Res

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Background The MVD gene mutations are identified in porokeratosis, which is considered a skin-specific autoinflammatory keratinization disease. However, the biological function of MVD gene remains largely unknown. Therefore, we analyzed the function of mvda gene, orthologous to the human MVD gene, in developing zebrafish. Methods Morpholino antisense oligonucleotide technique was used to generate mvda loss-of-function phenotypes. Knockdown of mvda was confirmed by RT-PCR and Sanger sequencing. Scanning and transmission electron microscopy were performed to analyze the morphology of the epidermis. Angiogenesis study was presented using the Tg(fli1a:EGFP)y1 transgenic strain. In addition, acridine orange staining was used to examine the apoptotic cells in vivo. Results As expected, the mvda morphants showed abnormal morphology of the epidermis. Moreover, we observed ectopic sprouts in trunk angiogenesis and impaired formation of the caudal vein plexus in the mvda-deficient zebrafish. Besides, increased apoptosis was found throughout the tail, heart, and eyes in mvda zebrafish morphants. Conclusions These findings indicated the essential role of mvda in the early development of zebrafish. This was the first in vivo knockdown study of the zebrafish mvda gene, which might offer insight into the biological function of the human MVD gene.

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Dermoscopy of Disseminated Superficial Actinic Porokeratosis

Cited by 28 publications

References 11 publications

Dermoscopic Features and Gene Mutation in the Mevalonate Pathway of Five Sporadic Patients with Porokeratosis

Dermoscopic Features and Gene Mutation in the Mevalonate Pathway of Five Sporadic Patients with Porokeratosis

Dermoscopy of porokeratosis of mibelli

Mvda is required for zebrafish early development

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