Dermoscopy of Hailey–Hailey disease in dark skin: a multicentric observational controlled study by the <i>International Dermoscopy Society</i> Task Force on “Imaging in Skin of Color”

Ankad, Balachandra S; Errichetti, Enzo; Lallas, Aimilios; Chauhan, Payal; Malani, Shailesh; Neema, Shekhar; Bhat, Yasmeen Jabeen; Vinay, Keshavamurthy; Behera, Biswanath; Khare, Soumil

doi:10.1111/ijd.16689

Cited by 3 publications

(7 citation statements)

References 9 publications

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“…Again, to the best of our knowledge, this feature has not been reported in previous papers. Similar to our findings, dotted blood vessels were also described in earlier publications, but the distribution was slightly different [ 25 – 28 ]. Oliveira et al .…”

Section: Discussionsupporting

confidence: 92%

“…Ankad et al . described white gray structureless areas in HHD patients with dark skin in a multicenter observational controlled study [ 28 ]. Another specific feature that may be a helpful clue to distinguish HHD from other inflammatory and bullous disorders is the crumbled fabric pattern.…”

Section: Discussionmentioning

confidence: 99%

“…Ankad et al . also described in patients with HHD erosions (100.0%, 23/23), having in the most of cases a linear and parallel linear shape [ 28 ]. Another characteristic dermoscopic finding of HHD in our patients were white dots surrounded by dotted blood vessels.…”

Section: Discussionmentioning

confidence: 99%

“…Ankad et al . reported the presence of dotted vessels in 95.6% (22/23) of patients with HHD, but in 56.5% (13/22) of patients the distribution was clustered, and in 39.1% (9/22) the distribution was unspecific [ 28 ]. In our patients, dotted blood vessels were homogeneously distributed throughout the skin lesions.…”

Section: Discussionmentioning

confidence: 99%

“…The first description of a dermoscopic pattern of skin lesions of patients with HHD treated with a CO 2 laser was reported in 2014 [ 24 ]. However, only two isolated reports and two case series studies assessing dermoscopic features of HHD have been published in the intervening years [ 25 – 28 ]. In contrast, the dermoscopic features of DD were described for the first time by Vázquez-López et al .…”

Section: Introductionmentioning

confidence: 99%

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Dermoscopy as a Noninvasive Diagnostic Tool for Hailey-Hailey Disease and Darier Disease

Kurzeja,

Rakowska,

Jasinska

et al. 2023

Dermatol Ther (Heidelb)

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Introduction Hailey-Hailey disease (HHD) and Darier disease (DD) are rare genetic disorders for which differential diagnosis, especially in less obvious cases, can be difficult. The diagnosis is based on the clinical picture and family history, and is confirmed by histopathologic examination. Dermoscopy is a noninvasive technique that is primarily used at the present time to diagnose skin cancers. However, in the past few years this technique has also been increasingly used as a noninvasive diagnostic tool of inflammatory skin diseases. The aim of the study was to evaluate whether dermoscopy is a useful noninvasive diagnostic tool for HHD and DD. Methods We performed an observational retrospective case series study involving 13 patients with HHD ( n = 8) and DD ( n = 5). The presence or absence of standardized dermoscopic features of inflammatory diseases (according to International Dermoscopy Society [IDS] guidelines) was assessed in these patients. Results The most distinctive feature of HHD was white clouds separated by pink furrows, visible in all cases (8/8; 100.0%). Another distinctive clue of HHD was the crumbled fabric pattern seen in six patients with HHD (6/8; 75.0%). These dermoscopic findings were not present in patients with DD. The most typical features of DD in the dermoscopic examination was star-like or oval-shaped yellow areas surrounded by whitish halo, visible in all patients (5/5; 100.0%). Another distinctive dermoscopic clue of DD was pinkish homogeneous structureless background, which was present in all patients (5/5, 100.0%). These latter two features were not observed in patients with HHD. Conclusion Dermoscopy reveals distinctive features of HHD and DD, respectively. Therefore, we conclude that dermoscopy can be an excellent complementary noninvasive tool in the diagnostic process of patients with HHD and DD.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dermoscopy as a Noninvasive Diagnostic Tool for Hailey-Hailey Disease and Darier Disease

Kurzeja,

Rakowska,

Jasinska

et al. 2023

Dermatol Ther (Heidelb)

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Hailey-Hailey disease: clinical, diagnostic and therapeutic update

Porro,

Arai Seque,

Miyamoto

et al. 2024

Anais Brasileiros de Dermatologia

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Dermoscopic Patterns of Genodermatoses: A Comprehensive Analysis

Plázár,

Meznerics,

Pálla

et al. 2023

Biomedicines

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(1) Background: Genodermatoses are a clinically and genetically heterogenous group of inherited skin disorders. Diagnosing inherited skin diseases is a challenging task due to their rarity and diversity. Dermoscopy is a non-invasive, easily accessible, and rapid tool used in dermatology not only for diagnostic processes but also for monitoring therapeutic responses. Standardized terminologies have been published for its proper use, reproducibility, and comparability of dermoscopic terms. (2) Methods: Here, we aimed to investigate dermoscopic features in various genodermatoses by conducting a systematic review and comparing its results to our own findings, data of patients diagnosed with genodermatoses at the Department of Dermatology, Venereology and Dermatooncology, Semmelweis University. (3) Results: Our systematic search provided a total of 471 articles, of which 83 reported both descriptive and metaphoric dermoscopic terminologies of 14 genodermatoses. The literature data were then compared to the data of 119 patients with 14 genodermatoses diagnosed in our department. (4) Conclusion: Dermoscopy is a valuable tool in the diagnosis of genodermatoses, especially when symptoms are mild. To enable the use of dermoscopy as an auxiliary diagnostic method, existing standardized terminologies should be extended to more genodermatoses.

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Dermoscopy of Hailey–Hailey disease in dark skin: a multicentric observational controlled study by the International Dermoscopy Society Task Force on “Imaging in Skin of Color”

Abstract: Hailey-Hailey disease (HHD) is an autosomal dominant genodermatosis related to mutations of the ATP2C1 gene (encodb P < 0.01 deemed as statistically significant. c Some lesions showed more than one subtype, so the sum of subtypes is more than 23.

Cited by 3 publications

References 9 publications

Dermoscopy as a Noninvasive Diagnostic Tool for Hailey-Hailey Disease and Darier Disease

Dermoscopy as a Noninvasive Diagnostic Tool for Hailey-Hailey Disease and Darier Disease

Hailey-Hailey disease: clinical, diagnostic and therapeutic update

Dermoscopic Patterns of Genodermatoses: A Comprehensive Analysis

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