Dermoscopy vs Capillaroscopy of Nontumoral Dermatoses

Vázquez‐López, Francisco; Marghoob, Ashfaq A.

doi:10.1001/archderm.140.5.617-a

Cited by 5 publications

(4 citation statements)

References 9 publications

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“…73,74 In perilesional skin, capillary loops assume an elongated disposition, with a ''hairpin'' aspect, parallel to the cutaneous surface, with a lengthened apex directed toward the marginal zone of the lesion. 70,75,76 Identification of ''bushy'' capillaries by VD can be helpful in addressing the diagnosis in unusual presentations, such as in palmar and/or plantar psoriasis, 77 psoriatic balanitis, 78 and scalp psoriasis, 79 particularly in those cases in which no other body sites were involved. Finally, the recognition of this pattern assumes a crucial importance in ''in vivo'' therapy monitoring, with a number of studies reporting morphological modifications and loop changes after local and systemic treatments.…”

Section: Psoriasismentioning

confidence: 99%

See 1 more Smart Citation

Dermatoscopy: Alternative uses in daily clinical practice

Micali

Lacarrubba

Massimino

et al. 2011

Journal of the American Academy of Dermatology

178

110

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Section: Psoriasismentioning

confidence: 99%

“…Finally, the recognition of this pattern assumes a crucial importance in ''in vivo'' therapy monitoring, with a number of studies reporting morphological modifications and loop changes after local and systemic treatments. 65,73,74,76 …”

Section: Psoriasismentioning

confidence: 99%

Dermatoscopy: Alternative uses in daily clinical practice

Micali

Lacarrubba

Massimino

et al. 2011

Journal of the American Academy of Dermatology

178

110

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“…The application of this technique to different skin conditions has gradually taken place, especially for inflammatory diseases such as psoriasis [162][163][164][165], lichen planus [166,167], rosacea [168] but also skin infestations (scabies [164,169,170], pediculosis [164,171,172], tungiasis [164,[173][174][175] and cutaneous leishmaniasis) [176], skin infections (molluscum contagiosum [177,178], viral warts and condylomas [170,[179][180][181] and lupus vulgaris [182]), hair disorders (alopecia areata, androgenetic alopecia and scarring alopecia) [164,183,184] and recently mycosis fungoides [185]. A further useful application of dermoscopy has been recently highlighted by Fargnoli et al, who showed the utility of this technique for monitoring nonmelanoma skin cancers during treatment [186].…”

Section: New Applications Of Dermoscopy For Different Skin Conditionsmentioning

confidence: 99%

Dermoscopy: distinguishing malignant tumors from benign

Gulia

Brunasso

Massone³

2012

Expert Review of Dermatology

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Dermoscopy has dramatically developed, becoming a well-established routine technique in many countries in the mid-1980s. Dermoscopy allows physicians to observe structures and colors otherwise not visible to unaided eyes, increasing melanoma diagnostic accuracy by up to 35%. Moreover, dermoscopy allows for increases in the number of diagnosed and excised melanomas together with a reduction in the number of unnecessary excisions. New data are continuously acquired mostly on melanoma diagnosis, follow-up of melanocytic lesions and nevogenesis. Short-term 3-month follow-up is the optimum time interval for identifying minimal changes in featureless melanomas. Nevertheless, long-term follow-up is similarly useful for the recognition of changes in melanomas with very low rates of growth. In the last few years a huge number of publications on dermoscopy have been published. The aim of this review is to summarize the most important recent advances in dermoscopy.

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“…Current methods that exist for assessing the skin atrophy potential in vivo in humans or animal models include X‐ray and ultrasound measurements of skin thickness, as well as dermoscopic observation of the skin surface . For X‐ray and ultrasound measurements, only structural thickness changes may be observed with low resolution, and the progression of functional changes such as cellular metabolism cannot be measured.…”

Section: Introductionmentioning

confidence: 99%

Longitudinal in vivo tracking of adverse effects following topical steroid treatment

Bower

Arp

Zhao

et al. 2016

Experimental Dermatology

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Topical steroids are known for their anti-inflammatory properties and are commonly prescribed to treat many adverse skin conditions such as eczema and psoriasis. While these treatments are known to be effective, adverse effects including skin atrophy are common. In this study, the progression of these effects is investigated in an in vivo mouse model using multimodal optical microscopy. Utilizing a system capable of performing two-photon excitation fluorescence microscopy (TPEF) of reduced nicotinamide adenine dinucleotide (NADH) to visualize the epidermal cell layers and second harmonic generation (SHG) microscopy to identify collagen in the dermis, these processes can be studied at the cellular level. Fluorescence lifetime imaging microscopy (FLIM) is also utilized to image intracellular NADH levels to obtain molecular information regarding metabolic activity following steroid treatment. In this study, fluticasone propionate (FP) treated, mometasone furoate (MF) treated, and untreated animals were imaged longitudinally using a custom-built multimodal optical microscope. Prolonged steroid treatment over the course of 21 days is shown to result in a significant increase in mean fluorescence lifetime of NADH, suggesting a faster rate of maturation of epidermal keratinocytes. Alterations to collagen organization and the structural microenvironment are also observed. These results give insight into the structural and biochemical processes of skin atrophy associated with prolonged steroid treatment.

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Dermoscopy vs Capillaroscopy of Nontumoral Dermatoses

Cited by 5 publications

References 9 publications

Dermatoscopy: Alternative uses in daily clinical practice

Dermatoscopy: Alternative uses in daily clinical practice

Dermoscopy: distinguishing malignant tumors from benign

Longitudinal in vivo tracking of adverse effects following topical steroid treatment

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