DERP6 (ELP5) and C3ORF75 (ELP6) Regulate Tumorigenicity and Migration of Melanoma Cells as Subunits of Elongator

Abstract

Background:Elongator is an acetylase complex that regulates cell migration. Results: DERP6 (ELP5) and C3ORF75 (ELP6) are characterized as Elongator subunits that control cell motility and tumorigenicity of melanoma cells. ELP5 ensures Elongator integrity by connecting ELP3 to ELP4. Conclusion: ELP5 and ELP6 are new players for migration and tumorigenicity of transformed cells. Significance: Elongator may be involved in both tumor initiation and progression.

Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine

“…Cell invasion of glioblastoma-, neuroblastoma-, and melanoma-derived cells also relies on Elp3 (Close et al, 2006(Close et al, , 2012. Further, our results show that colonosphere formation from colon cancer-derived cells was greatly dependent on Elp3.…”

Elongator, a conserved complex required for wobble uridine modifications in Eukaryotes

“…3,[79][80][81][82][83][84][85] Consistent with yeast, mutations in Elongator genes in the mouse M. musculus, the worm C. elegans, the plant A. thaliana and human cause defects in formation of wobble uridine modifications ( Table 2). 82,[86][87][88] In vitro, Elongator complex purified from HeLa cells have histone H3 and H4 acetyltransferase activity and depletion of the human homolog hELP1, IKAP (I kappa B kinase complex associated protein) in fibroblasts, leads to hypoacetylation of histone H3, transcription impairment and cell migration defects.…”

α-Tubulin Acetylation Elevated in Metastatic and Basal-like Breast Cancer Cells Promotes Microtentacle Formation, Adhesion, and Invasive Migration

“…αTAT1 is thought to be the major tubulin acetyltransferase in vivo , but histone acetyltransferases (HATs) ELP3 (39) and Gcn5 (44) have also been shown to acetylate α-tubulin. Interestingly, overexpression of these enzymes are linked to progression of acute lymphoblastic leukemia (ALL) (45), enhanced lung cancer growth (46), and increased motility in melanoma cells (47). HAT inhibitors have also been shown to have potent anti-tumor activity against triple-negative breast cancer xenografts in vivo (48).…”