Des-Gamma-Carboxyprothrombin (PIVKA-II) Levels in Maternal Serum throughout Gestation

Nishiguchi, Tomoki; Matsuyama, Kaoru; Kobayashi, Takao; Kanayama, Naohiro

doi:10.1055/s-2005-872443

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…Women, however, had an early age of onset manifesting during the reproductive age. The reasons for such an early age of onset could be pregnancy-induced thrombophilic status or use of oral contraceptives [26,27]. The Mala-D oral contraceptive contains ethinyl oestradiol, whose consumption beyond 50 mg/day increases the risk for DVT [28].…”

Section: Discussionmentioning

confidence: 99%

Hyperhomocysteinemia and the compound heterozygous state for methylene tetrahydrofolate reductase are independent risk factors for deep vein thrombosis among South Indians

Naushad

Jamal

Angalena

et al. 2007

Blood Coagulation &Amp; Fibrinolysis

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To investigate the role of methylene tetrahydrofolate reductase (MTHFR) (677 C-->T and 1298 A-->C), factor V (1691 G-->A), factor II (20210 G-->A) genetic polymorphisms and hyperhomocysteinemia in the aetiology of deep vein thrombosis (DVT) in 163 cases and 163 controls. Polymerase chain reaction-restriction fragment length polymorphism was used for genotyping, reverse-phase high-performance liquid chromatography for plasma homocysteine, and Student's t-test and Fisher exact tests were used for statistical analysis. Elevated mean plasma homocysteine levels were observed in DVT cases irrespective of gender differences. Homocysteine elevation above the 95th percentile of the control group associated with 9.4-fold and 7.6-fold increased risk for DVT in men and women, respectively. Genotyping showed the MTHFR 677CT/1298AC genotype (i.e. compound heterozygosity) is associated with 3.5-fold risk for thrombosis. The factor V Leiden mutation frequency was higher in DVT cases, but not statistically significant; however, genetic predisposition to this mutation was associated with early age of DVT onset. Factor II mutation was absent in cases and controls. Co-segregation of two or more risk factors was associated with 11.7-fold increased risk for thrombosis. This study projects that hyperhomocysteinemia and compound heterozygous state for MTHFR are independent risk factors for DVT among South Indians.

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Section: Discussionmentioning

confidence: 99%

Hyperhomocysteinemia and the compound heterozygous state for methylene tetrahydrofolate reductase are independent risk factors for deep vein thrombosis among South Indians

Naushad

Jamal

Angalena

et al. 2007

Blood Coagulation &Amp; Fibrinolysis

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“…Японские ученые привели данные об уровнях витамина K при беременности. Так, T. Nishiguchi et al в 2005 г. оценивали уровни витамина K путем определения PivKAii у беременных (n = 135) на протяжении всего периода гестации [13]. У всех женщин уровни PivKAii превышали пороговые допустимые показатели, при этом наблюдалось постепенное повышение уровней белка с увеличением срока беременности с максимумом в iii триместре.…”

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Аnti-inflammatory effects of vitamin K on women's health

et al. 2019

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This article presents the latest research data on the role of vitamin K in the implementation of its multiple non-classical extra-coagulation effects associated with the regulation of a number of physiological and pathological processes in the human body. In recent years, numerous studies have been performed on vitamin K function to better understand the effects of this micronutrient and its significance in various biological reactions. Vitamin K is well known to be a cofactor of the -carboxylation of a number of proteins, which is necessary for their activation and is part of the so-called vitamin K cycle. The cycle enzymes, metabolites and vitamin K-dependent proteins are identified and expressed in many cells and tissues of the human body: skin, lungs, liver, kidneys, vascular endothelium, nervous and bone tissues, reproductive (endometrium, ovaries, placenta) and immune systems. There were analyzed the main mechanisms of vitamin K action through vitamin K-dependent proteins. The results of epidemiological and experimental studies prove the association of reduced vitamin K levels with the increased risk of cardiovascular diseases, overall mortality, insulin resistance, metabolic syndrome, type 2 diabetes mellitus, progression of rheumatoid arthritis and osteoporosis. On the contrary, vitamin K increased intake has a positive effect on the immune and nervous systems, as well as on a number of other somatic pathologies, including breakdowns in the reproductive sphere. These data confirm the multifunctional role of vitamin K in various organs and systems of organism, presenting as high potential further studies in the field of determining vitamin K levels.

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Fetal Intraventricular Bleeding Possibly due to Maternal Vitamin K Deficiency

Minami¹,

Furuhashi²,

Minami³

et al. 2008

Fetal Diagn Ther

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We report a rare case of fetal intraventricular bleeding possibly due to maternal vitamin K deficiency. A 20-year-old woman was admitted to our hospital due to impending premature delivery and loss of dietary intake at 28 weeks of gestation. Her blood examination showed metabolic alkalosis, prolonged prothrombin time, and extremely high level of plasma des-gamma-carboxyprothrombin (protein induced by vitamin K absence, PIVKA-II). Intraventricular hemorrhage was demonstrated by ultrasonography 6 days after admission. She delivered a 2,288-gram girl infant at 40 weeks of gestation. Cranial computerized tomography and magnetic resonance images obtained postnatally demonstrated a reduced cerebral parenchyma adjacent to the interior side of the right lateral ventricle and the deficit of left cerebellum. The infant’s head control was insufficient and central impaired hearing was noted at 6 months of life.

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Des-Gamma-Carboxyprothrombin (PIVKA-II) Levels in Maternal Serum throughout Gestation

Cited by 3 publications

References 6 publications

Hyperhomocysteinemia and the compound heterozygous state for methylene tetrahydrofolate reductase are independent risk factors for deep vein thrombosis among South Indians

Hyperhomocysteinemia and the compound heterozygous state for methylene tetrahydrofolate reductase are independent risk factors for deep vein thrombosis among South Indians

Аnti-inflammatory effects of vitamin K on women's health

Fetal Intraventricular Bleeding Possibly due to Maternal Vitamin K Deficiency

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