DES-igning the future of drug delivery: A journey from fundamentals to drug delivery applications

Kapre, Sumedha; Palakurthi, Sushesh Srivatsa; Jain, Ankit; Palakurthi, Srinath

doi:10.1016/j.molliq.2024.124517

Cited by 8 publications

(2 citation statements)

References 192 publications

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“…Additionally, the mucoadhesive properties of chitosan enhance the residence time of drug-loaded nanoparticles at mucosal surfaces, thereby improving drug absorption and bioavailability. Because of their unique properties, DESs are also especially suited for drug delivery [281]. As an example of this synergy, Silva et al [263] reported a system wherein curcumin dissolved in ChCl/glycerol was encapsulated within beads formed via ionotropic gelation with chitosan and alginate.…”

Section: Property/activitymentioning

confidence: 99%

Strategies to Prepare Chitin and Chitosan-Based Bioactive Structures Aided by Deep Eutectic Solvents: A Review

Durante-Salmerón,

Fraile-Gutiérrez,

Gil-Gonzalo

et al. 2024

Catalysts

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Chitin and chitosan, abundant biopolymers derived from the shells of crustaceans and the cell walls of fungi, have garnered considerable attention in pharmaceutical circles due to their biocompatibility, biodegradability, and versatile properties. Deep eutectic solvents (DESs), emerging green solvents composed of eutectic mixtures of hydrogen bond acceptors and donors, offer promising avenues for enhancing the solubility and functionality of chitin and chitosan in pharmaceutical formulations. This review delves into the potential of utilizing DESs as solvents for chitin and chitosan, highlighting their efficiency in dissolving these polymers, which facilitates the production of novel drug delivery systems, wound dressings, tissue engineering scaffolds, and antimicrobial agents. The distinctive physicochemical properties of DESs, including low toxicity, low volatility, and adaptable solvation power, enable the customization of chitin and chitosan-based materials to meet specific pharmaceutical requirements. Moreover, the environmentally friendly nature of DESs aligns with the growing demand for sustainable and eco-friendly processes in pharmaceutical manufacturing. This revision underscores recent advances illustrating the promising role of DESs in evolving the pharmaceutical applications of chitin and chitosan, laying the groundwork for the development of innovative drug delivery systems and biomedical materials with enhanced efficacy and safety profiles.

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Section: Property/activitymentioning

confidence: 99%

Strategies to Prepare Chitin and Chitosan-Based Bioactive Structures Aided by Deep Eutectic Solvents: A Review

Durante-Salmerón,

Fraile-Gutiérrez,

Gil-Gonzalo

et al. 2024

Catalysts

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show abstract

“…DESs exhibit a unique combination of properties such as low toxicity, biodegradability, and importantly tunable physicochemical characteristics [71][72][73]. Despite the fact that the extent of their environmental friendliness has recently become a topic of debate [74][75][76][77], DESs showcase remarkable potential across various domains of pharmaceutical applications, including drug synthesis, formulation, and extraction processes [78][79][80][81][82][83][84][85][86][87][88]. Noteworthily, DESs have been shown to be effective solubilizers of ibuprofen [89,90] and ketoprofen [91].…”

Section: Introductionmentioning

confidence: 99%

Experimental and Machine-Learning-Assisted Design of Pharmaceutically Acceptable Deep Eutectic Solvents for the Solubility Improvement of Non-Selective COX Inhibitors Ibuprofen and Ketoprofen

Cysewski,

Jeliński,

Przybyłek

et al. 2024

Molecules

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Deep eutectic solvents (DESs) are commonly used in pharmaceutical applications as excellent solubilizers of active substances. This study investigated the tuning of ibuprofen and ketoprofen solubility utilizing DESs containing choline chloride or betaine as hydrogen bond acceptors and various polyols (ethylene glycol, diethylene glycol, triethylene glycol, glycerol, 1,2-propanediol, 1,3-butanediol) as hydrogen bond donors. Experimental solubility data were collected for all DES systems. A machine learning model was developed using COSMO-RS molecular descriptors to predict solubility. All studied DESs exhibited a cosolvency effect, increasing drug solubility at modest concentrations of water. The model accurately predicted solubility for ibuprofen, ketoprofen, and related analogs (flurbiprofen, felbinac, phenylacetic acid, diphenylacetic acid). A machine learning approach utilizing COSMO-RS descriptors enables the rational design and solubility prediction of DES formulations for improved pharmaceutical applications.

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Eutectic Mixtures of APIs: A way to Improve the Physiochemical Properties and Oral Bioavailability of the Drugs

Singh,

Sharma,

Singh Raman@

et al. 2024

ChemistrySelect

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Eutectic mixtures (EMs) are consisted of two or more components with a specific composition and melting point, have received a lot of attention in pharmaceutical research due to their potential to improve the physicochemical properties and oral bioavailability of active pharmaceutical ingredients (APIs). This review summarizes the most recent research on eutectic combinations of APIs and their use in pharmaceutical formulations. First, the fundamental concepts and characteristics of EMs are reviewed, focusing on their distinct thermodynamic properties and possible advantages in drug delivery systems. The tactics used for forming and characterizing EMs are then described, including techniques such as thermal analysis, spectroscopy, and microscopy. The review delves into the diverse approaches utilized to enhanced the solubility, dissolution rate and oral absorption of poorly water‐soluble APIs through the formation of EMs, including the selection of suitable co‐formers, optimization of composition ratios, and formulation techniques. Furthermore, notable examples of EMs in pharmaceutical development are presented, showcasing their efficacy in enhancing the bioavailability of a wide range of drug compounds across different therapeutic classes. Overall, this review covers the potential of EMs as a promising approach to address formulation challenges and improve the therapeutic performance of APIs, paving the way for the development of more effective and patient‐friendly drug products.

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DES-igning the future of drug delivery: A journey from fundamentals to drug delivery applications

Cited by 8 publications

References 192 publications

Strategies to Prepare Chitin and Chitosan-Based Bioactive Structures Aided by Deep Eutectic Solvents: A Review

Strategies to Prepare Chitin and Chitosan-Based Bioactive Structures Aided by Deep Eutectic Solvents: A Review

Experimental and Machine-Learning-Assisted Design of Pharmaceutically Acceptable Deep Eutectic Solvents for the Solubility Improvement of Non-Selective COX Inhibitors Ibuprofen and Ketoprofen

Eutectic Mixtures of APIs: A way to Improve the Physiochemical Properties and Oral Bioavailability of the Drugs

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