Desafiando a la inequidad de Latinoamérica

Population Kidney Health. A New Paradigm for Chronic Kidney Disease Management

“…There is an abundance of evidence showing the relationships between social and environmental factors and CKD. Across the literature reviewed, country-level socioeconomic factors like health expenditure [ 7 , 18 ], development level [ 17 ], and the size of the kidney care workforce [ 1 , 11 , 21 , 22 ], individual-level sociodemographic characteristics like gender [ 9 , 12 , 13 , 14 , 27 ], education [ 2 , 34 ], household income [ 33 , 34 , 44 , 45 ], race and ethnicity [ 8 , 23 , 29 ], as well as environmental factors like exposure to agrochemicals and high-temperatures [ 6 , 44 ], were identified as consequential to CKD outcomes. However, even though there is an increasing number of studies indicating the relevance of these social determinants, our review showed that public health policies for CKD management are still predominantly focused on health-related individual risk factors [ 8 , 43 ].…”

“…This is a form of chronic interstitial nephritis of multicausal origin whether it be by thermal stress, specific pesticides, genetic factors, infectious agents or social aspects [ 6 ]. Renal aggressors, facilitated by the inhospitable environment in which vulnerable individuals work, highlight the multicausal aspect of disease development, facilitated by existing inequalities in Latin America and the Caribbean [ 7 ]. If we begin with the proposal of measuring, analyzing and monitoring social inequalities in health, we are accepting that the social position of the individual is at the undisputed center of a broad conceptualization of health because it would allow the measurement of the real impact of population risk factors in relation to the possibility of getting individually sick.…”

Precision medicine implementation challenges for APOL1 testing in chronic kidney disease in admixed populations

“…Firstly, it is important to know the proportion of individuals with high-risk genotypes and how many of them could develop ESRD in the general population. Precision medicine approaches are largely skewed towards European populations, with fewer studies representing people from African, Latin American, Caribbean, and Indigenous ancestry ( Depine and Martínez, 2018 ; Burgos-Calderón et al, 2021 ; Hoy and Ordunez, 2022 ). Many factors contribute to geneticists favoring cohorts of European ancestries, such as the previous existence of large datasets generated by well-established organizations, and the difficulties of obtaining funding for studies focused on ethnic minorities ( Popejoy and Fullerton, 2016 ; Hindorff et al, 2018 ).…”

Caracterización clínica y epidemiológica de la enfermedad renal poliquística en un Centro de referencia de Cuarto Nivel del Caribe Colombiano (2008-2022)

“…El impacto real es importante, esto debido a que muchos pacientes a pesar de tener alguna enfermedad renal y ser asintomáticos pasan muchos años sin intervenciones terapéuticas y de esta manera ocurre el deterioro severo en la función renal llegando hacia la insuficiencia, generando una carga mórbida relevante (26,27). Dado el alto impacto de la progresión de la enfermedad renal poliquística hacia la necesidad de terapia renal sustitutiva, así como la carga que esta condición genera, así mismo la escaza información sobre su caracterización epidemiológica en Colombia, resulta de gran interés su impacto clínico y su papel en la salud pública.…”