Desaminoanthracyclines from the antibotic complex ciclamycin.

A new 16-membered tetraene macrolide JBIR-100 from a newly identified Streptomyces species

“…According to database searches, it is a new compound, which was named cinerubin K. About 500 naturally occurring Anthracycline antibiotics were reported in the literature [61,105,410] , containing at least one sugar moiety. They are characterized by their antibacterial and antitumor activities, e.g cinerubins [411] , ciclamycins [412] , musettamycin [413] , pyrromycin [398] . Antibacterial and antifungal activities of the isolated compounds (267, 269, 271~273, 275 and 276) were semi-quantitatively determined using the agar diffusion method with 9 mm paper discs and 20 µg /disk.…”

Production, optimization and purification of an antifungal compound from Streptomyces capoamus MTCC 8123

“…The strain Streptomyces capoamus is well known for the production of ciclamycin, ciclacidine, and capoamycin, an anthracyclin-class antitumor complex (Bieber et al, 1987;Gonclaves et al, 1968;Hayakawa et al, 1985;Martins and Maior, 2003) but to the best of our knowledge this strain has not been reported to produce antifungal compounds. The antifungal compound produced by this strain is fairly stable to the pH range 5-8.…”

The Anthracyclinic Complex Retamycin, 1. Structure Determination of the Major Constituents

“…Further confirmation of the proposed structures was obtained by high field :H nmr spectroscopy. Detailed analysis by multiple decouplings and comparison with data from ciclamycins 4 (15) and 5 (16), which contain the same sugars in comparable positions, allowed the exact assignment of almost all peaks except those in the region between 1.5 and 2.1 ppm corresponding to the positions 2 were recorded on a Broker WM 400 spectrometer using CDC1, as solvent and TMS as an internal standard. Fabms were run in bis(2-hydroxyethyl) sulfide as the matrix on a Kratos MS 80 instrument, equipped with post-acceleration detector and high-field magnet, using a Xenon beam of 6 keV energy and a current of ca.…”