Desarrollo de una nueva constante de difusion no afectada por cambios en el volumen alveolar

A Simple Method of Correcting Diffusing Capacity for Alveolar Volume Reduction in Restrictive Lung Diseases

“…The mean value and standard deviation (SD) for each parameter were: TL^," 103 ± 12%: Kco= 102 ± 15% and V., = 102 ± 7% of predicted value 13,10], The lung transfer factor was measured with the single-breath technique of Ogilvie et al [19] as modi fied by Cotes [3]. A PK Morgan Transfer Test, Model C (P.K.…”

“…The influence o f Va on TLC0 was later corrected by m eans o f an experimental equation, obtained by Gaensler and Smith [6], Zco: Corrected Diffusing Capacity O ur group has recently [10] proposed a corrected diffusing capacity (Zc0), that of fers im portant advantages in comparison with Kco and TLC0, as it is not significantly influenced by variations o f Va in the dif ferent subjects examined. This factor im plies an exponential relationship between TLco and Va.…”

“…When Va decreases, TLC0 also de creases linearly, but Kc0 increases expon entially [2,9,12,14,16,17,20,21], This makes the interpretation o f these parameters difficult in patients with re duced lung volume. Recently our group [10] has developed a correction coefficient, Z, o f transfer factor, which allows correc-tion of TLco according to the alveolar volume in which the test is performed. The aim of the present work is to determ ine its clinical applicability in subjects with re duction of lung volume.…”