The chapter aims to discuss obstacles that affect the successful implementation of nursing training programs from learner nurses’ perspectives. The scope of the obstacles is limited to the clinical and classroom settings, where the nursing curriculum is implemented, and therefore the chapter will discuss obstacles to the nursing training program in hospitals/clinics and educational institutions. The chapter is a summary of a quantitative cross-sectional research study that collected data from all 190 learner nurses. Learner nurses were sampled with a stratified random sampling, which resulted in 129 samples of learner nurses. An electronic self-designed questionnaire written in English was sent to learner nurses via their university students’ email to complete it. Descriptive statistics were utilized to describe the frequency of learner nurses regarding the R425 program curriculum review. The source of information, in this chapter, is the research finding obtained from learner nurses, using a quantitative research approach and literature, which highlight that the success of health education could be observed when barriers to nursing program implementation have been eliminated. The chapter provides learning opportunities to program designers and leaders of the educational and healthcare facilities where the nursing training programs are implemented.