Descemet Stripping Endothelial Keratoplasty for Fuchs' Endothelial Corneal Dystrophy

Wacker, Katrin; Baratz, Keith H.; Maguire, Leo J.; McLaren, Jay W.; Patel, Sanjay V.

doi:10.1016/j.ophtha.2015.09.023

Cited by 96 publications

(87 citation statements)

References 34 publications

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“…In contrast to our findings, however, a recent prospective study could not detect a correlation between BCVA and HOAs of the anterior corneal surface in FECD patients (Wacker et al. ). The analysis was a Pearson correlation analysis on 34 subjects at 5 years post‐op, and there may have been insufficient power to detect an influence.…”

Section: Discussioncontrasting

confidence: 99%

“…Another explanation might be that the decrease of anterior HOAs in the study by Wacker et al. () was noticeably less (10%) than the 38% decrease found here. This discrepancy might be explained by differences in measuring techniques as Wacker et al.…”

Section: Discussioncontrasting

confidence: 72%

“…; Wacker et al. ). Considering Catquest‐9SF, we evaluated the effect size, which is a measure of the improvement in patient‐reported outcome (methods section).…”

Section: Discussionmentioning

confidence: 97%

See 2 more Smart Citations

Fuchs’ endothelial corneal dystrophy: a controlled prospective study on visual recovery after endothelial keratoplasty

Nielsen

Ivarsen

Kristensen

et al. 2016

Acta Ophthalmologica

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 72%

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Fuchs’ endothelial corneal dystrophy: a controlled prospective study on visual recovery after endothelial keratoplasty

Nielsen

Ivarsen

Kristensen

et al. 2016

Acta Ophthalmologica

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“…As reported in the literature, ultrathin grafts are associated with faster visual recovery and a postoperative visual acuity comparable with Descemet membrane endothelial keratoplasty over time. 4,5 An inverse association between the quantity of transplanted stromal tissue and visual outcome has also been reported in pre-Descemetic deep anterior lamellar keratoplasty. [6][7][8] In addition, we have observed a decreased rate of intraand perioperative (unpublished data) complications when using ultrathin large-diameter DSAEK grafts.…”

Section: To the Editormentioning

confidence: 87%

Ultrathin Grafts for DSAEK With a Single Microkeratome Pass

Romano

Steger

Brunner

et al. 2016

Cornea

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“…Specifically, we noted an ECD of 1,548 ± 456 cells/mm 2 in DSAEK group and 1,052 ± 567 cells/mm 2 in PK group at postoperative 2 years. Wacker et al [8] conducted a 5-year study of Descemet Stripping Endothelial Keratoplasty for Fuchs' endothelial corneal dystrophy, and reported an ECD at postoperative 2 and 5 years of 1,837 ± 551 cells/mm 2 and 1,322 ± 487 cells/mm 2 , respectively. Likewise, a study by Price et al [9] reported that at postoperative 3 years, the median ECD was 1,763 cells/mm 2 following DSAEK and 1,636 cells/mm 2 following PK, with a median 3-year cell loss for DSAEK and PK of 59% and 61% ( p = 0.70), respectively.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Long-term Clinical Outcomes between Descemet's Stripping Automated Endothelial Keratoplasty and Penetrating Keratoplasty in Patients with Bullous Keratopathy

Kim

Lim

Byun

et al. 2016

Korean J Ophthalmol

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PurposeTo compare 2-year clinical outcomes of Descemet's stripping automated endothelial keratoplasty (DSAEK) and penetrating keratoplasty (PK) in patients with bullous keratopathy.MethodsA retrospective chart review was performed to obtain 2 years of follow-up data of DSAEK or PK at a single center from March 2009 to September 2012. The study comprised 15 eyes of DSAEK and 11 eyes of PK. Outcome measures included best-corrected visual acuity (BCVA), spherical and keratometric changes, central corneal thickness, endothelial cell density, intraocular pressure, and postoperative complications. Graft survival rate was assessed by Kaplan-Meier survival analysis.ResultsThere were no differences in patient baseline characteristics between the two groups. At postoperative 2 years, better BCVA of 0.69 ± 0.51 logarithm of the minimum angle of resolution (logMAR) was found after DSAEK compared to 0.88 ± 0.48 logMAR after PK. Refractive cylinder in DSAEK and PK was −2.60 ± 1.53 and −6.00 ± 1.05 diopters (D), respectively, and keratometric cylinder was 3.27 ± 3.70 and 6.34 ± 3.51 D, respectively, at postoperative 2 years. The difference of mean spherical equivalents between postoperative 1 month and 2 years was 0.84 D after DSAEK and 2.05 D after PK. A hyperopic shift of 1.17 D was present after 2 years of DSAEK. The mean endothelial cell density at postoperative 2 years was 1,548 ± 456 cells/mm2 for DSAEK and 1,052 ± 567 cells/mm2 for PK, with a cell loss of 19.96% vs. 52.38%, respectively when compared to postoperative 1 month. No significant difference in central corneal thickness was found between DSAEK and PK (592 ± 75 vs. 563 ± 90 µm, respectively). Finally, the 2-year survival rate did not differ significantly between DSAEK and PK (93.3% vs. 81.8%, respectively, p = 0.344).ConclusionsCompared to PK, DSAEK provided more stable refractive errors with better visual outcome, lower endothelial cell loss, and a lower rate of graft rejection at postoperative 2 years in patients with bullous keratopathy.

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Descemet Stripping Endothelial Keratoplasty for Fuchs' Endothelial Corneal Dystrophy

Cited by 96 publications

References 34 publications

Fuchs’ endothelial corneal dystrophy: a controlled prospective study on visual recovery after endothelial keratoplasty

Fuchs’ endothelial corneal dystrophy: a controlled prospective study on visual recovery after endothelial keratoplasty

Ultrathin Grafts for DSAEK With a Single Microkeratome Pass

Comparison of Long-term Clinical Outcomes between Descemet's Stripping Automated Endothelial Keratoplasty and Penetrating Keratoplasty in Patients with Bullous Keratopathy

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