2022
DOI: 10.1055/a-1751-3411
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Descemet-Stripping ohne Transplantat bei Fuchsʼscher endothelialer Hornhautdystrophie?

Abstract: ZusammenfassungTraditionell wird das Hornhautendothel als postmitotisch angesehen, sodass von einer spontanen Regeneration nach Verlust von Endothelzellen (z. B. im Rahmen der Fuchsʼschen endothelialen Hornhautdystrophie) nicht ausgegangen wird. Dennoch konnte in mehreren Fällen beobachtet werden, dass eine ödematöse Hornhaut nach Entfernung eines kleineren Areals der Descemet-Membran aufklart. Der posteriore Aspekt dieses Bereichs wurde von Hornhautendothelzellen wieder bedeckt. Hieraus entstand ein… Show more

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“…In the last decade, more and more clinical studies have reported successful treatment with excellent visual outcomes of moderate FECD with removal only of the affected central endothelium (DSO—Descemet stripping only, DWEK—Descemet without endothelial keratoplasty). It is based on the patient’s own healthy peripheral corneal endothelial-cell migration [ 4 , 5 , 6 , 7 , 8 ]. Treatment of FECD without corneal transplantation is an elegant way of avoiding the possible consequences of tissue transplantation (inflammation in the anterior chamber, transplant-tissue rejection, life-long immunomodulatory treatment, etc.)…”
Section: Introductionmentioning
confidence: 99%
“…In the last decade, more and more clinical studies have reported successful treatment with excellent visual outcomes of moderate FECD with removal only of the affected central endothelium (DSO—Descemet stripping only, DWEK—Descemet without endothelial keratoplasty). It is based on the patient’s own healthy peripheral corneal endothelial-cell migration [ 4 , 5 , 6 , 7 , 8 ]. Treatment of FECD without corneal transplantation is an elegant way of avoiding the possible consequences of tissue transplantation (inflammation in the anterior chamber, transplant-tissue rejection, life-long immunomodulatory treatment, etc.)…”
Section: Introductionmentioning
confidence: 99%