Ludwig's Angina is a rapidly progressing acute infectious process affecting the submandibular, sublingual, and submental spaces. If not promptly treated, it can be life-threatening and lead to sepsis and airway obstruction. Early detection, immediate and precise intervention including drainage, elimination of the causative factor, airway management, and antibiotic therapy are crucial for successful treatment. This manuscript presents a clinical case of Ludwig's Angina that evolved to mediastinitis and aorta rupture, resulting in a decease of a 23 years-old woman, despite treatment efforts.