Descending nociceptive inhibition is modulated in a time-dependent manner in a double-hit model of chronic/tonic pain

Parent, Alexandre J.; Tétreault, Pascal; Roux, Mélisange; Belleville, Karine; Longpré, Jean‐Michel; Beaudet, Nicolas; Goffaux, Philippe; Sarret, Philippe

doi:10.1016/j.neuroscience.2015.11.065

Cited by 17 publications

(17 citation statements)

References 39 publications

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“…By the visceral hypersensitivity, pain sensation is amplified and sometimes stimuli that normally do not cause pain become painful. As a corollary, the hypersensitivity would promote hyperactivation of descending pain inhibitory pathways . In fact, alteration in the inhibition of spinal nociceptive transmission (ie, descending inhibition pathways) has been reported in patients with IBS .…”

Section: Discussionmentioning

confidence: 99%

“…As a corollary, the hypersensitivity would promote hyperactivation of descending pain inhibitory pathways. 40 In fact, alteration in the inhibition of spinal nociceptive transmission (ie, descending inhibition pathways) has been reported in patients with IBS. [41][42][43][44] Moreover, chronic stress, a risk factor for IBS, increases 5-HT biosynthesis in the rostral ventromedial medulla, which is one of the origins of the descending pain inhibitory pathways.…”

Section: Discussionmentioning

confidence: 99%

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Exogenous serotonin regulates colorectal motility via the 5‐HT₂ and 5‐HT₃ receptors in the spinal cord of rats

Nakamori

Naitou

Sano

et al. 2017

Neurogastroenterology Motil

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Exogenous serotonin regulates colorectal motility via the 5‐HT₂ and 5‐HT₃ receptors in the spinal cord of rats

Nakamori

Naitou

Sano

et al. 2017

Neurogastroenterology Motil

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“…Animals were randomly allocated to sham or CCI group. Neuropathic pain was induced with CCI as previously described by Bennett and Xie29 with a 5-0 chromic gut suture 30. In brief, after the intraperitoneal injection of sodium pentobarbital (35 mg/kg), the left sciatic nerve was loosely ligated with four sutures distant by 1–1.5 mm at the upstream of the nerve trifurcation of tibial, sural, and the common peroneal nerve.…”

Section: Methodsmentioning

confidence: 99%

Chronic constriction injury of sciatic nerve changes circular RNA expression in rat spinal dorsal horn

Cao

Deng

Liu

et al. 2017

JPR

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BackgroundMechanisms of neuropathic pain are still largely unknown. Molecular changes in spinal dorsal horn may contribute to the initiation and development of neuropathic pain. Circular RNAs (circRNAs) have been identified as microRNA sponges and involved in various biological processes, but whether their expression profile changes in neuropathic pain condition is not reported.MethodsTo test whether neuropathic pain influences circRNA expression, we developed a sciatic chronic constriction injury (CCI) model in rats. The CCI ipsilateral spinal dorsal horns of lumbar enlargement segments (L3–L5) were collected, and the total RNA was extracted and subjected to Arraystar Rat circRNA Microarray. Quantitative real-time polymerase chain reaction (qPCR) was used to confirm the circRNA expression profile. To estimate functions of differential circRNAs, bioinformatics analyses including gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes Pathway analyses were performed for the top 100 circRNAs and circRNA–microRNA networks were constructed for the top 10 circRNAs.ResultscircRNA microarrays showed that 469 circRNAs were differentially expressed between CCI and sham-operated rats (fold change ≥2). In all, 363 of them were significantly upregulated, and the other 106 were downregulated in the CCI group. Three of them (circRNA_013779, circRNA_008008, and circRNA_003724) overexpressed >10 times after CCI insult. Expression levels of eight circRNAs were verified using qPCR. GO analysis revealed that thousands of predicted target genes were involved in the biological processes, cellular component, and molecular function; in addition, dozens of these genes were enriched in the Hippo signaling pathway, MAPK signaling pathway, and so on. Competing endogenous RNAs analysis showed that circRNA_008008 and circRNA_013779 are the two largest nodes in the circRNA–microRNA interaction network of the top 10 circRNAs.ConclusionCCI resulted in a comprehensive expression profile of circRNAs in the spinal dorsal horn in rats. CircRNAs in the dorsal horn could be helpful to reveal molecular mechanisms of neuropathic pain.

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“…Furthermore, inflammation showed to increase the excitability in the dorsal horn and the RVM, which later on enhanced descending pain modulation (Schaible et al., ; Ren and Dubner, ; Terayama et al., ). It was hypothesized that the enhanced inhibition would gradually disappear and result in a classical hyperalgesic pain response (Ren and Dubner, ; Parent et al., ). It was assumed that due to a progressive dysfunction of endogenous analgesia this system cannot compensate long‐term painful states (Millan, ).…”

Section: Discussionmentioning

confidence: 99%

Unimpaired endogenous pain inhibition in the early phase of complex regional pain syndrome

Kumowski

Hegelmaier

Kolbenschlag

et al. 2017

European Journal of Pain

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Descending nociceptive inhibition is modulated in a time-dependent manner in a double-hit model of chronic/tonic pain

Cited by 17 publications

References 39 publications

Exogenous serotonin regulates colorectal motility via the 5‐HT₂ and 5‐HT₃ receptors in the spinal cord of rats

Exogenous serotonin regulates colorectal motility via the 5‐HT₂ and 5‐HT₃ receptors in the spinal cord of rats

Chronic constriction injury of sciatic nerve changes circular RNA expression in rat spinal dorsal horn

Unimpaired endogenous pain inhibition in the early phase of complex regional pain syndrome

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Descending nociceptive inhibition is modulated in a time-dependent manner in a double-hit model of chronic/tonic pain

Cited by 17 publications

References 39 publications

Exogenous serotonin regulates colorectal motility via the 5‐HT2 and 5‐HT3 receptors in the spinal cord of rats

Exogenous serotonin regulates colorectal motility via the 5‐HT2 and 5‐HT3 receptors in the spinal cord of rats

Chronic constriction injury of sciatic nerve changes circular RNA expression in rat spinal dorsal horn

Unimpaired endogenous pain inhibition in the early phase of complex regional pain syndrome

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Exogenous serotonin regulates colorectal motility via the 5‐HT₂ and 5‐HT₃ receptors in the spinal cord of rats

Exogenous serotonin regulates colorectal motility via the 5‐HT₂ and 5‐HT₃ receptors in the spinal cord of rats