Abstract:Infection of human cells by the SARS-CoV2 relies on its binding to a specific receptor and subsequent fusion of the viral and the host cell membranes. The fusion peptide (FP), a short peptide segment in the spike protein, plays a central role in the initial penetration of the virus into the host cell membrane, followed by the fusion of the two membranes. Here, we use an extensive array of molecular dynamics (MD) simulations taking advantage of the Highly Mobile Membrane Mimetic (HMMM) model, to investigate the… Show more
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