Describing Natural History and Exploring Risk Factors for Kidney Function Decline in Persons With CKD of Uncertain Etiology in Sri Lanka

Hewavitharana, Pasan; Schensul, Stephen L.; Lee, Edison; Montez‐Rath, Maria E.; Senarathne, Sachintha; Liu, Sai; Harold, Kaitlin; Hewapathiranage, Santhushya; Erandika, N.; Abeysundara, Hemalika T. K.; Yu, Xue; Bhalla, Vivek; Fire, Andrew; Levin, Adeera; Anand, Shuchi; Vlahos, Penny; Chandrajith, Rohana; Nanayakkara, Nishantha

doi:10.1016/j.ekir.2023.04.010

Cited by 2 publications

(3 citation statements)

References 23 publications

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“…Future research could build on our observed disease progression variation within endemic areas to interrogate environmental differences within these subregions, and therefore, narrow potential candidate causes of CKDu. 6 Aekplakorn, W et al in 2021 found although the prevalence of CKDu in Thailand was low overall, there remained areas with higher risk. Our study may be a model for higher-middle income country, where despite overall economic and healthcare improvement, much work needs to be done to increase the awareness and reduce the risk for CKDu in underserved regions.…”

Section: Resultsmentioning

confidence: 99%

Factor Associated of Chronic Kidney Disease of Uncertain Etiology: A Comprehensive Systematic Review

Natan,

Alkhaliq

2024

JARMHS

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Background: Recent interest in chronic kidney disease of non-traditional causes, also named as chronic kidney disease of unknown etiology (CKDu) has identified both individual and environmental/occupational risk factors. The aim: The aim of this study to show factor associated of chronic kidney disease of uncertain etiology. Methods: By the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020, this study was able to show that it met all of the requirements. This search approach, publications that came out between 2014 and 2024 were taken into account. Several different online reference sources, like Pubmed, SagePub, and Sciencedirect were used to do this. It was decided not to take into account review pieces, works that had already been published, or works that were only half done. Result: the results of our search get 91 articles, whereas the results of our search on SagePub get 1976 articles, on Sciencedirect 14.279 articles. Records remove before screening are 5676, so we get 10670 articles fos screening. We included five research that met the criteria. Conclusion: Different multifactorial etiologies like chronic exposure to dehydration, heat stress, agrochemicals, heavy metals, intake of fructose-rich drinks, frequent use of self-prescribed non- steroidal anti-inflammatory drugs (NSAIDS), lower income and genetics were proposed in its development.

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Section: Resultsmentioning

confidence: 99%

Factor Associated of Chronic Kidney Disease of Uncertain Etiology: A Comprehensive Systematic Review

Natan,

Alkhaliq

2024

JARMHS

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“…Overall, 1246 (39.4%) patients had a family history of diabetes and 2306 (72.9%) had that of hypertension. The median eosinophilic granulocyte count was 0.123 ×10 9 /L (IQR, 0.0625 ×10 9 /L-0.212 ×10 9 /L). Additionally, the eosinophilic granulocyte count was higher in men than in women (2.844×10 9 /L vs. 2.368 ×10 9 /L, p < 0.001), and patients whose condition progressed to ESRD had higher eosinophilic granulocyte counts (2.904×10 9 /L vs. 2.632 ×10 9 /L, p = 0.026).…”

Section: Baseline Characteristicsmentioning

confidence: 99%

“…CKD is a global health concern because of its high morbidity and mortality rates [3,4]. Proteinuria, blood pressure control, dyslipidemia, and hyperuricemia have been con rmed as the main risk factors for CKD progression [5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Association of peripheral eosinophil count with chronic kidney disease progression risk: a retrospective cohort study

Ren,

Zhang,

et al. 2024

Preprint

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Background: Eosinophilia is common in renal diseases; however, the role of peripheral eosinophils in chronic kidney disease (CKD) requires further evaluation. Therefore, we aimed to determine whether an eosinophil count increase is related to the occurrence of end-stage renal disease (ESRD). Methods: This single-center, observational, retrospective study was conducted between January 2016 and December 2018 in Hangzhou, China. The study included 3163 patients, categorized into four groups according to peripheral eosinophil count (PEC) quartile values (Q1 PEC, ≤0.0625×109/L; Q2, 0.0625–0.1223×109/L; Q3, 0.1224–0.212×109/L; Q4, ≥0.212×109/L). The main outcome was ESRD development during follow-up. We evaluated the relationship between serum eosinophil count, demographic and clinical information, and ESRD incidence. Cox proportional hazards models were used to examine the association between the PEC and risk of progression to ESRD. Kaplan-Meier survival curves were compared between Q1 and Q4 PECs using the log-rank test. Results: A total of 3163 patients with CKD were included in this cohort, of whom 1254 (39.6%) were female individuals and the median (interquartile range [IQR]) age was 75 [64, 85] years and the median (IQR) estimated glomerular filtration rate was 55.16 [45.19, 61.19] mL/min/1.73 m2. The median PEC was 0.1224×109/L (IQR, 0.0625–0.212). Among the 3163 patients with CKD, 273 (8.6%) developed ESRD during a median follow-up time of 443.8 [238.8, 764.9] days. Individuals in the highest PEC quartile had a 66.2% higher ESRD risk than those in the lowest quartile (hazard ratio, 1.662; 95% confidence interval, 1.165–2.372). The results from the Kaplan-Meier survival curves confirmed the conclusion. Conclusions: Alongside traditional risk factors, patients with CKD and an elevated PEC are more likely to develop ESRD. Therefore, more attention should be paid to those patients with CKD who have a high PEC.

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Describing Natural History and Exploring Risk Factors for Kidney Function Decline in Persons With CKD of Uncertain Etiology in Sri Lanka

Cited by 2 publications

References 23 publications

Factor Associated of Chronic Kidney Disease of Uncertain Etiology: A Comprehensive Systematic Review

Factor Associated of Chronic Kidney Disease of Uncertain Etiology: A Comprehensive Systematic Review

Association of peripheral eosinophil count with chronic kidney disease progression risk: a retrospective cohort study

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