Describing universal Strongyloides serologic screening among pediatric intestinal and liver transplant recipients

Abstract

Background Strongyloides spp hyperinfections are a worldwide phenomenon that proves fatal for solid organ transplant recipients. Screening protocols to guide prophylaxis management vary institution to institution from universal to epidemiology driven. Our institution initiated a universal screening protocol regardless of travel history and exposure to ensure no cases were missed. Methods In this study, we describe the outcomes of three Strongyloides sero‐positive children whom underwent intestinal or liver transplantation and the experience of universal screening at a tertiary care county hospital in South Florida. Results Among the 66 intestine and liver pediatric transplant recipients who were screened for Strongyloides antibodies, only three were identified to be sero‐positive via the screening mechanism. Two of three had significant epidemiology risk factors. None of the patients reviewed were found to have developed hyperinfection. However, reflecting on the experience represented by our series of pediatric patients, the risk of any complication related to Strongyloides status appears low. Even among this South Florida population whom come from or travel to endemic regions are in contact with sero‐positive individuals, very few illustrate sero‐positivity. Conclusion While institutions continue to analyze the cost‐benefit of universal testing vs. universal prophylaxis vs. targeted screening, the decision must encompass the patient population, rolling cumulative incidence, and morbidity and mortality related to this disease.

Seroprevalence of Strongyloides stercoralis in Patients about to Receive Immunosuppressive Treatment in Gran Canaria (Spain)

“…In our study, 2 of 48 (4.7%) organ recipients were found to have IgG antibodies to S. stercoralis , one of whom (2.38%) was Spanish. In the literature, the prevalence of infection in this type of patient in a non-endemic area range from 3 to 12.4% [ 36 , 38 , 39 , 40 ].…”