Description of a novel approach for intraperitoneal drug delivery and the related device

Solaß, Wiebke; Hetzel, Alexander; Nadiradze, Giorgi; Sagynaliev, Emil; Reymond, Marc A.

doi:10.1007/s00464-012-2148-0

Cited by 185 publications

(139 citation statements)

References 18 publications

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“…In vivo experiments on the living animal are probably the best model for optimizing therapeutic [5,6], as compared to ex vivo experiments [4] or experiments using cadavers [7]. Although the use of live animals continues to be necessary to protect human animal health, it is desirable to replace such procedures by other methods not entailing the use of live animals [8].…”

Section: Discussionmentioning

confidence: 99%

A new ex vivo model for optimizing distribution of therapeutic aerosols: the (inverted) bovine urinary bladder

Schnelle

Weinreich

Kibat

et al. 2017

Pleura and Peritoneum

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Background: Development of Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) requires adequate preclinical models. Methods: The model should be easy to use, reproducible and cost-effective. It should have a volume similar to the human abdominal cavity, and an oval shape. The inner surface should be lined with serosa. The model should allow pharmacological and biological analysis, including histology. No living animals should be used. Results: The fresh urinary bladder is explanted from an adult bovine in the slaughterhouse. A 4-cm incision is performed into the bladder neck. The bladder can be inverted through the incision, which allows exposition of the serosa on its inner side. A balloon trocar is inserted through the incision and a ligature placed, ensuring full tightness. The therapeutic capnoperitoneum is installed. The bovine bladder has a volume somewhat smaller (2-3 L) than the human abdominal cavity (3-5 L). Costs are minimal. There is no significant bacteriological contamination. Manipulation is simple. Conclusions: The (inverted) bovine urinary bladder is an innovative and versatile ex vivo model for optimizing drug delivery with therapeutic aerosols both onto the mucosa or the serosa. This model can be used for pharmaceutical Quality-by-Design approaches and will replace a large number of experiments in the animal.

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Section: Discussionmentioning

confidence: 99%

A new ex vivo model for optimizing distribution of therapeutic aerosols: the (inverted) bovine urinary bladder

Schnelle

Weinreich

Kibat

et al. 2017

Pleura and Peritoneum

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“…Some experimental studies have shown higher drug penetration in tumoural nodes with higher and controlled intra-abdominal pressure. Solass et al [6] showed higher drug penetration in the intra-abdominal pressure group called therapeutic pneumoperitoneum. Facy et al [7] showed a different Oxaliplatin penetration under different thermal conditions and intra-abdominal pressure in a porcine model.…”

Section: Discussionmentioning

confidence: 99%

Hyperthermic chemotherapy intra-abdominal laparoscopic approach: development of a laparoscopic model using CO₂ recirculation system and clinical translation in peritoneal carcinomatosis

Sánchez-García

Padilla

Campos

et al. 2017

International Journal of Hyperthermia

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Hyperthermic chemotherapy intra-abdominal laparoscopic approach: development of a laparoscopic model using CO 2 recirculation system and clinical translation in peritoneal carcinomatosis Susana S anchez-Garc ıa, David Padilla-Valverde, Pedro Villarejo-Campos, Esther P. Garc ıa-Santos and Jes us Mart ın-Fern andez Department of General Surgery, University General Hospital, Medicine School, University of Castilla la Mancha, Ciudad Real, Spain ABSTRACT Introduction: Hyperthermic intraperitoneal chemotherapy (HIPEC) is an effective treatment for peritoneal carcinomatosis (PC). Laparoscopic surgery is performed in the treatment of colorectal and appendiceal cancer, and PC from diverse origin in selected patients. HIPEC management by laparoscopic approach after cytoreductive surgery (CRS) completed locoregional treatment of PC, and may be feasible and safe after appropriate patient selection. Objective: Development of an experimental model of HIPEC by laparoscopic approach, with CO 2 recirculation. Clinical translation in two patients with PC and low peritoneal cancer index. Material and methods: We performed CRS in a porcine model of 5 pigs (35-38 kg) by laparoscopic approach. Laparoscopic HIPEC by CO 2 recirculation system was performed; laparoscopic access was used for catheter input and output placement (Paclitaxel 175 mg/m 2 for 60 min at 42 C). The experimental variables were: blood gases, haemodynamic and intra-abdominal and central temperature. Clinical model application was performed in three cases with PC from colorectal origin. Results: No statistically significant differences was found in blood gases, haemodynamic or temperature in the experimental study. In clinical study, there were no technical complications during laparoscopic-HIPEC approach, and we observed no changes in haemodynamic variables during the procedure. Conclusions: CRS and HIPEC laparoscopic model by CO 2 recirculation system is safe and feasible technique in selected patients, that include low PC index, local and accessible tumour recurrences or high-risk of PC tumours.

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“…The working mechanism of PIPAC is based on local administration of cytotoxic agents on the tumoral surface in the abdominal cavity. The aerosol form accomplishes homogeneous drug distribution [30], while it is believed that the high intra-abdominal pressure enhances tissue penetration and antitumor effects [31,32]. As a consequence, a low dose of chemotherapy can be used, causing low systemic drug uptake and toxicity [29,33].…”

Section: Current Clinical Management Of Pcmentioning

confidence: 99%

Nanomedicine-based intraperitoneal therapy for the treatment of peritoneal carcinomatosis — Mission possible?

Dakwar

Shariati

Willaert

et al. 2017

Advanced Drug Delivery Reviews

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Intraperitoneal (IP) drug delivery represents an attractive strategy for the local treatment of peritoneal carcinomatosis (PC). Over the past decade, a lot of effort has been put both in the academia and clinic in developing IP therapeutic approaches that maximize local efficacy while limiting systemic side effects. Also nanomedicines are under investigation for the treatment of tumors confined to the peritoneal cavity, due to their potential to increase the peritoneal retention and to target drugs to the tumor sites as compared to free drugs. Despite the progress reported by multiple clinical studies, there are no FDA approved drugs or formulations for specific use in the IP cavity yet. This review discusses the current clinical management of PC, as well as recent advances in nanomedicines-based IP delivery.We address important challenges to be overcome towards designing optimal nanocarriers for IP therapy in vivo.

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Description of a novel approach for intraperitoneal drug delivery and the related device

Abstract: This device and the related approach significantly improve both distribution and penetration of a test substance into the peritoneal cavity in a large animal model. This might be a significant progress in treating intraperitoneal disease, in particular peritoneal carcinomatosis.

Cited by 185 publications

References 18 publications

A new ex vivo model for optimizing distribution of therapeutic aerosols: the (inverted) bovine urinary bladder

A new ex vivo model for optimizing distribution of therapeutic aerosols: the (inverted) bovine urinary bladder

Hyperthermic chemotherapy intra-abdominal laparoscopic approach: development of a laparoscopic model using CO₂ recirculation system and clinical translation in peritoneal carcinomatosis

Nanomedicine-based intraperitoneal therapy for the treatment of peritoneal carcinomatosis — Mission possible?

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Description of a novel approach for intraperitoneal drug delivery and the related device

Abstract: This device and the related approach significantly improve both distribution and penetration of a test substance into the peritoneal cavity in a large animal model. This might be a significant progress in treating intraperitoneal disease, in particular peritoneal carcinomatosis.

Cited by 185 publications

References 18 publications

A new ex vivo model for optimizing distribution of therapeutic aerosols: the (inverted) bovine urinary bladder

A new ex vivo model for optimizing distribution of therapeutic aerosols: the (inverted) bovine urinary bladder

Hyperthermic chemotherapy intra-abdominal laparoscopic approach: development of a laparoscopic model using CO2 recirculation system and clinical translation in peritoneal carcinomatosis

Nanomedicine-based intraperitoneal therapy for the treatment of peritoneal carcinomatosis — Mission possible?

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Hyperthermic chemotherapy intra-abdominal laparoscopic approach: development of a laparoscopic model using CO₂ recirculation system and clinical translation in peritoneal carcinomatosis