2016
DOI: 10.1155/2016/4231683
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Description of a Rare Case of Nodular Fasciitis of the Apical Aspect of the Upper Buccal Sulcus

Abstract: This report describes a rare case of nodular fasciitis (NF) of the oral cavity, discussing the clinical, histological, and immunohistochemical characteristics. Histopathologic diagnosis of this type of lesion can be challenging due to its differential diagnosis, which principally includes sarcoma. The patient presented with a painless, well-defined nodule, reported as increasing in size, located at the apical aspect of the upper left buccal sulcus. Histologically, the lesion revealed spindle cell proliferation… Show more

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Cited by 6 publications
(4 citation statements)
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“…In this case, the spindle-shaped myofibroblast-like cells stained positive for smooth muscle actin. This was also observed in the cases that were reported by lloyd et al, Ikebe et al and Souza et al [4,17,18] however, NF has to be distinguished from other benign tumors of myofibroblastic origin. Inflammatory myofibroblastic tumor (IMT) is generally larger than NF, tends to occur at a younger age, and is composed of longer fascicles of spindle cells in an inflammatory background that is rich in plasma cells.…”
Section: Commentarysupporting
confidence: 57%
“…In this case, the spindle-shaped myofibroblast-like cells stained positive for smooth muscle actin. This was also observed in the cases that were reported by lloyd et al, Ikebe et al and Souza et al [4,17,18] however, NF has to be distinguished from other benign tumors of myofibroblastic origin. Inflammatory myofibroblastic tumor (IMT) is generally larger than NF, tends to occur at a younger age, and is composed of longer fascicles of spindle cells in an inflammatory background that is rich in plasma cells.…”
Section: Commentarysupporting
confidence: 57%
“…The nodular fasciitis diagnosis was generally based on a CT scan, sometimes associated with an MRI scan, ultrasound image and/or incisional biopsy. The gold standard therapy is surgical resection as documented by the literature 1,2,5–59 . In five cases, the authors preferred a wait‐and‐see approach, 3,11,60,61 while in another seven cases, the authors reported a spontaneous regression of the pathology 42 .…”
Section: Discussionmentioning
confidence: 99%
“…Typical histologic findings include a myxoid and, in some cases, highly cellular stroma, exhibiting abundant mitotic activity, with the absence of cellular atypia. Myxoid degeneration may also be observed, while other areas are more fibrotic and hyalinized, displaying evidence of adjacent microhemorrhage with granulation tissue [14]. Differential diagnoses are sarcoma with differentiation to myofibroblasts, such as low-grade myofibroblastic sarcoma, undifferentiated pleomorphic sarcoma, and deep fibrous histiocytoma.…”
Section: Discussionmentioning
confidence: 99%