Description of an influenza outbreak in a French university hospital and risk factors of nosocomial influenza

Bocquet, A.; Wintenberger, C.; Lupo, Julien; Morand, Patrice; Pavèse, Patricia; Gallouche, Meghann; Lina, Bruno; Bouillet, Laurence; Bosson, Jean‐Luc; Mallaret, Marie-Reine; Landelle, Caroline

doi:10.1007/s10096-020-04070-9

Cited by 9 publications

(12 citation statements)

References 13 publications

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“…Bacterial pathogens are the most commonly recorded causing microorganisms of nosocomial LRTIs [ 7 , 8 ]. However, particularly during respiratory virus seasons, nosocomial LTRI outbreaks with viral pathogens occur regularly [ 9 , 10 ]. To provide healthcare facilities with useful mitigation strategies for respiratory viruses, the clinical practice guidelines for seasonal influenza were published by the Infectious Diseases Society of America [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Risk factors for nosocomial SARS-CoV-2 infections in patients: results from a retrospective matched case–control study in a tertiary care university center

Aghdassi

Schwab

Diaz

et al. 2022

Antimicrob Resist Infect Control

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Background Factors contributing to the spread of SARS-CoV-2 outside the acute care hospital setting have been described in detail. However, data concerning risk factors for nosocomial SARS-CoV-2 infections in hospitalized patients remain scarce. To close this research gap and inform targeted measures for the prevention of nosocomial SARS-CoV-2 infections, we analyzed nosocomial SARS-CoV-2 cases in our hospital during a defined time period. Methods Data on nosocomial SARS-CoV-2 infections in hospitalized patients that occurred between May 2020 and January 2021 at Charité university hospital in Berlin, Germany, were retrospectively gathered. A SARS-CoV-2 infection was considered nosocomial if the patient was admitted with a negative SARS-CoV-2 reverse transcription polymerase chain reaction test and subsequently tested positive on day five or later. As the incubation period of SARS-CoV-2 can be longer than five days, we defined a subgroup of “definite” nosocomial SARS-CoV-2 cases, with a negative test on admission and a positive test after day 10, for which we conducted a matched case–control study with a one to one ratio of cases and controls. We employed a multivariable logistic regression model to identify factors significantly increasing the likelihood of nosocomial SARS-CoV-2 infections. Results A total of 170 patients with a nosocomial SARS-CoV-2 infection were identified. The majority of nosocomial SARS-CoV-2 patients (n = 157, 92%) had been treated at wards that reported an outbreak of nosocomial SARS-CoV-2 cases during their stay or up to 14 days later. For 76 patients with definite nosocomial SARS-CoV-2 infections, controls for the case–control study were matched. For this subgroup, the multivariable logistic regression analysis revealed documented contact to SARS-CoV-2 cases (odds ratio: 23.4 (95% confidence interval: 4.6–117.7)) and presence at a ward that experienced a SARS-CoV-2 outbreak (odds ratio: 15.9 (95% confidence interval: 2.5–100.8)) to be the principal risk factors for nosocomial SARS-CoV-2 infection. Conclusions With known contact to SARS-CoV-2 cases and outbreak association revealed as the primary risk factors, our findings confirm known causes of SARS-CoV-2 infections and demonstrate that these also apply to the acute care hospital setting. This underscores the importance of rapidly identifying exposed patients and taking adequate preventive measures.

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Section: Introductionmentioning

confidence: 99%

Risk factors for nosocomial SARS-CoV-2 infections in patients: results from a retrospective matched case–control study in a tertiary care university center

Aghdassi

Schwab

Diaz

et al. 2022

Antimicrob Resist Infect Control

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“…In Darley et al(67) this finding was only for C difficile , whereas hospital-acquired MRSA rates did not differ by accommodation type. Bocquet et al(78) and Munier-Marion et al(87) found reduced nosocomial influenza infections in single rooms and one study showed a reduced risk of norovirus infection. (82) By contrast, McDonald and colleagues(71) noted reduced infection rates for Enterococcus spp, C difficile , and MRSA.…”

Section: Resultsmentioning

confidence: 99%

“…78,81,82,86,90,96,97) Two found a decrease in nosocomial infections in single rooms P one overall(78) and one for diarrhoea in gastrointestinal and neurosurgical units,(81) but the latter found no difference between accommodation types in a cardiological unit. In two large studies in Finland (n=1,927 and n=5,119), Kinnula and colleagues(96,97) saw increases in hospital-acquired infections among children admitted to shared accommodation in an infectious disease ward because there was no grouping by aetiology.…”

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confidence: 99%

The clinical, humanistic, and economic outcomes, including experiencing of patient safety events, associated with admitting patients to single rooms compared with shared accommodation for acute hospital admissions. A narrative synthesis systematic literature review

Bertuzzi¹,

Martin

Clarke

et al. 2022

Preprint

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Objectives: Assess the impact of single rooms versus multioccupancy accommodation on inpatient health-care outcomes and processes. Design: Systematic review. Setting: Hospitals and secondary care units. Participants: Inpatients receiving routine, emergency, high-dependency, or intensive care with a named type of hospital accommodation. Main outcome measures: Qualitative synthesis of findings. Results: Of 4,861 citations initially identified, 215 were deemed suitable for full-text review, of which 145 were judged to be relevant to this review. Five main method types were reported: 60 before-and-after comparisons, 75 contemporaneous comparisons, 18 qualitative studies of accommodation preferences, 10 evidence syntheses. All studies had methodological issues that potentially biased the results by not adjusting for confounding factors that are likely to have contributed to the outcomes. Ninety-two papers compared clinical outcomes for patients in single rooms versus shared accommodation, but no clearly consistent conclusions could be drawn about overall benefits of single rooms versus shared accommodation (multioccupancy rooms, bays, or wards). Single rooms were most likely to be associated with a small overall clinical benefit for the most severely ill patients, especially neonates in intensive care. Patients who preferred single rooms tended to do so for privacy, and for reduced disturbances. By contrast, men, older adults, children, and adolescents were more likely to prefer shared accommodation to avoid loneliness. While shared accommodation seemed to be the most cost-effective approach for construction, greater costs associated with building single rooms were small and likely to be recouped over time by other efficiencies. Conclusions: The lack of difference between inpatient accommodation types in a large number of studies suggests that there would be little effect on clinical outcomes, particularly in routine care. Patients in intensive care areas are most likely to benefit from single rooms. Most patients preferred single rooms for privacy and some preferred shared accommodation for avoiding loneliness.

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“…In our study, cases were more often hospitalized with a roommate than controls. Hospitalization in double or multiple occupancy rooms and sharing a common space were identified as risk factors for nosocomial influenza [21] , [39] and as a risk factors for nosocomial COVID-19 [8] . Nevertheless, this difference was not significant in the adjusted analysis which considered exposure to contagious patients and HCWs.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for nosocomial COVID-19 in a French university hospital

Dinh¹,

Gallouche²,

Terrisse³

et al. 2023

Infectious Diseases Now

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Description of an influenza outbreak in a French university hospital and risk factors of nosocomial influenza

Cited by 9 publications

References 13 publications

Risk factors for nosocomial SARS-CoV-2 infections in patients: results from a retrospective matched case–control study in a tertiary care university center

Risk factors for nosocomial SARS-CoV-2 infections in patients: results from a retrospective matched case–control study in a tertiary care university center

The clinical, humanistic, and economic outcomes, including experiencing of patient safety events, associated with admitting patients to single rooms compared with shared accommodation for acute hospital admissions. A narrative synthesis systematic literature review

Risk factors for nosocomial COVID-19 in a French university hospital

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