Description of B Lymphocytes and Plasma Cells, Complement, and Chemokines/Receptors in Acute Liver Allograft Rejection

Krukemeyer, Manfred Georg; Moeller, Johannes; Morawietz, Lars; Rudolph, Birgit; Neumann, Ulf; Theruvath, Tom P.; Neuhaus, P.; Krenn, Veit

doi:10.1097/01.tp.0000132324.14207.8b

Cited by 79 publications

(61 citation statements)

References 25 publications

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“…Yang et al showed that HBD-1 is chemotactic for dendritic cells and T-cells via the CCR6 chemokine receptor (24). Intriguingly, CCR6 expressing cells have been demonstrated in liver transplant recipients with acute rejection (25).…”

Section: Discussionmentioning

confidence: 99%

Characterization of Urinary Peptide Biomarkers of Acute Rejection in Renal Allografts

O’Riordan

Orlova

Podust³

et al. 2007

American Journal of Transplantation

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Section: Discussionmentioning

confidence: 99%

Characterization of Urinary Peptide Biomarkers of Acute Rejection in Renal Allografts

O’Riordan

Orlova

Podust³

et al. 2007

American Journal of Transplantation

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“…To date, however, no comprehensive analysis of capillary C4d staining in liver allograft biopsies has been performed. In a recent preliminary study, Krukemeyer et al found C4d deposits along the portal capillaries of biopsy specimens from patients with acute liver allograft rejection (59). However, no correlation with anti-donor antibodies was performed.…”

Section: Humoral Rejection In Other Solid Organ Allograftsmentioning

confidence: 96%

Humoral Rejection of Organ Allografts

Moll

Pascual

2005

American Journal of Transplantation

101

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In recent years, the deleterious clinical consequences of recipient de novo alloantibody production against HLA antigens from human organ allografts have been extensively investigated. In kidney transplantation, the identification of the complement C4d fragment in peritubular capillaries as a specific marker for humoral rejection has helped to define and characterize distinct clinical alloantibody-mediated syndromes. This knowledge is relevant for patient management as new therapeutic strategies to remove and control anti-donor antibody production, particularly in the setting of acute humoral rejection, have been reported. For recipients of nonrenal organ allografts such as heart transplant recipients, de novo anti-HLA alloantibody may also be important, although more studies are needed before clear guidelines can be proposed.

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“…The presence of CD20 + B cells correlated with glucocorticoid resistance and graft loss. B cell infiltrates have also been described in human liver transplants undergoing AR (21), as well as cardiac transplants (22,23).…”

Section: B Cells In Allograft Rejectionmentioning

confidence: 98%

CD20+ B Cells: The Other Tumor-Infiltrating Lymphocytes

Nelson

2010

The Journal of Immunology

359

278

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Tumor-infiltrating CD8+ T cells are strongly associated with patient survival in a wide variety of human cancers. Less is known about tumor-infiltrating CD20+ B cells, which often colocalize with T cells, sometimes forming organized lymphoid structures. In autoimmunity and organ transplantation, T cells and B cells collaborate to generate potent, unrelenting immune responses that can result in extensive tissue damage and organ rejection. In these settings, B cells enhance T cell responses by producing Abs, stimulatory cytokines, and chemokines, serving as local APCs, and organizing the formation of tertiary lymphoid structures that sustain long-term immunity. Thus, B cells are an important component of immunological circuits associated with persistent, rampant tissue destruction. Engagement of tumor-reactive B cells may be an important condition for generating potent, long-term T cell responses against cancer.

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Description of B Lymphocytes and Plasma Cells, Complement, and Chemokines/Receptors in Acute Liver Allograft Rejection

Cited by 79 publications

References 25 publications

Characterization of Urinary Peptide Biomarkers of Acute Rejection in Renal Allografts

Characterization of Urinary Peptide Biomarkers of Acute Rejection in Renal Allografts

Humoral Rejection of Organ Allografts

CD20+ B Cells: The Other Tumor-Infiltrating Lymphocytes

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