The present case report describes the management of two alpacas undergoing repair of a metatarsal and a distal tibial fracture, respectively. Both animals received ketamine and medetomidine intramuscularly, resulting in deep sedation. Endotracheal intubation was performed, and general anaesthesia was maintained with sevoflurane. An in‐plane ultrasound‐guided sciatic nerve block was performed at the level of the mid‐thigh with bupivacaine 0.5% before surgery as part of the analgesic treatment. Meloxicam was administered. Heart rate, arterial blood pressure and respiratory rate were stable during the surgery, despite the use of a low end‐tidal sevoflurane concentration. No opioids were required intraoperatively. Duration of the anaesthesia was 205 and 255 minutes, respectively. Extubation was performed 12 and 6 minutes after discontinuing sevoflurane administration, respectively. In both cases, regional anaesthesia of the sciatic nerve improved the intraoperative management of alpacas that required surgical treatment for fractures.