Description of eight human infections caused by Bacteroides pyogenes in a tertiary hospital of northern Spain

Vecilla, Domingo Fernández; Gutiérrez, Mikel Joseba Urrutikoetxea; Matheus, Mary Paz Roche; López, Itziar Angulo; Vivanco, Cristina Aspichueta; Muro, Felicitas Elena Calvo; Arco, José Luis Díaz de Tuesta del

doi:10.1016/j.anaerobe.2023.102759

Cited by 2 publications

(4 citation statements)

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“…Notably, as above reported for saliva, members of the genus Fusobacterium are widely recognized as potential pathogen of the oral cavity (Goldstein et al 2017 , Crowley et al 2024 , Krieger et al 2024 ), while members of the genus Actinomyces have been positively correlated with oral diseases in dogs (Oba et al 2021 ), particularly A. oricola that was isolated for the first time from a human dental abscess (Hall et al 2003 ). Similarly, the methane producer M. oralis and the sulphate-reducing D. oralis have been strictly associated with severe periodontal disease both in humans and dogs (Cross et al 2018 , Niemiec et al 2021 ), while B. pyogenes have been frequently described as an animal pathogen (Fernandez Vecilla et al 2023 , Sadhwani et al 2024 ). In addition to periodontitis biomarker, Porphyromonas macacae and Bergeyella spp.…”

Section: Resultsmentioning

confidence: 99%

Species-level characterization of saliva and dental plaque microbiota reveals putative bacterial and functional biomarkers of periodontal diseases in dogs

Alessandri,

Fontana,

Mancabelli

et al. 2024

FEMS Microbiology Ecology

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Periodontal diseases are among the most common bacterial-related pathologies affecting the oral cavity of dogs. Nevertheless, the canine oral ecosystem and its correlations with oral disease development are still far from being fully characterized. In this study, the species-level taxonomic composition of saliva and dental plaque microbiota of 30 healthy dogs was investigated through a shallow shotgun metagenomics approach. The obtained data allowed not only to define the most abundant and prevalent bacterial species of the oral microbiota in healthy dogs, including members of the genera Corynebacterium and Porphyromonas, but also to identify the presence of distinct compositional motifs in the two oral micro-niches as well as taxonomical differences between dental plaques collected from anterior and posterior teeth. Subsequently, the salivary and dental plaque microbiota of 18 dogs affected by chronic gingival inflammation and 18 dogs with periodontitis were compared to those obtained from the healthy dogs. This analysis allowed the identification of bacterial and metabolic biomarkers correlated with a specific clinical status, including members of the genera Porphyromonas and Fusobacterium as microbial biomarkers of a healthy and diseased oral status, respectively, and genes predicted to encode for metabolites with anti-inflammatory properties as metabolic biomarkers of a healthy status.

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Section: Resultsmentioning

confidence: 99%

Species-level characterization of saliva and dental plaque microbiota reveals putative bacterial and functional biomarkers of periodontal diseases in dogs

Alessandri,

Fontana,

Mancabelli

et al. 2024

FEMS Microbiology Ecology

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“…An in‐vitro study showed susceptibility rates to Bacteroides fragilis of 77% and non‐fragilis Bacteroides species of 78% and 79% in two different groups. 7 Fernández et al 2023 2 recently described 8 cases of B pyogenes infection with all samples having in vitro susceptibility to moxifloxacin, metronidazole and amoxicillin/clavulanic acid. It may be that combined treatment and a longer duration of treatment with metronidazole was required for resolution.…”

Section: Discussionmentioning

confidence: 99%

“…The figure is a coronal contrast‐enhanced CT Chest in September 2016. Cavitating lesions were present in the left lower lobe 1 and right middle lobe 2 . A clip in the upper abdomen from previous splenectomy is indicated.…”

Section: Case Reportmentioning

confidence: 99%

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Prolonged Bacteroides pyogenes infection in a patient with multiple lung abscesses

Lee,

Walls,

Anderson

et al. 2024

Respirology Case Reports

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Bacteroides pyogenes is naturally found in the oral microbiome of cats and dogs and hence exposure, especially bites from these animals, is a major risk factor for human infections. B pyogenes is known to cause infections that persist despite antibiotic treatment and can have serious clinical outcomes. We present a novel case of complex lung abscesses associated with B pyogenes infection. A 55 year old man presents with a 3‐month history of productive cough, night sweats, and 5 kg weight loss. An initial chest radiograph revealed mass‐like opacities in the right upper lobe (RUL), right middle lobe (RML), and left lower lobe (LLL). Over the next 4 years the patient underwent multiple investigations and antimicrobial treatments until resolution of the abscesses. We believe that metronidazole in combination with moxifloxacin was a key component in the clinical cure of this patient.

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Description of eight human infections caused by Bacteroides pyogenes in a tertiary hospital of northern Spain

Cited by 2 publications

References 20 publications

Species-level characterization of saliva and dental plaque microbiota reveals putative bacterial and functional biomarkers of periodontal diseases in dogs

Species-level characterization of saliva and dental plaque microbiota reveals putative bacterial and functional biomarkers of periodontal diseases in dogs

Prolonged Bacteroides pyogenes infection in a patient with multiple lung abscesses

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