Description of four new HLA alleles in the Finnish population: A*03:283N, A*68:167, C*03:327, C*03:361

Abstract

New HLA alleles found in the Finnish population: A*03:283N, A*68:167, C*03:327 and C*03:361.

MICA and MICB allele assortment in Finland

“…The Finnish HLA landscape differs from those of other European populations; some HLA alleles and haplotypes have been enriched in the Finnish population and are rare or non-existent elsewhere. 37,38 The discovery of the new MIC alleles described here supports the idea of distinctive HLA landscape of the Finnish population. In addition, the recently reported MICB*039 allele from one individual of unknown ethnic origin, had a frequency of 0.019 in the Finnish population.…”

“…35,36 Finland is also a genetic outlier in its HLA variation, with several HLA alleles or haplotypes enriched in Finland but rare elsewhere. 37,38 In the present study we determined the frequencies of MICA and MICB alleles at 2-field resolution in the Finnish population. The MICA and MICB allele and haplotype frequencies together with five novel low-frequency alleles are reported and compared with frequencies of other populations.…”

“…The Finnish population is a genetic mixture of Western and Eastern European populations with Siberian influence 31–34 with bottlenecks and sub‐isolates in history 35,36 . Finland is also a genetic outlier in its HLA variation, with several HLA alleles or haplotypes enriched in Finland but rare elsewhere 37,38 . In the present study we determined the frequencies of MICA and MICB alleles at 2‐field resolution in the Finnish population.…”

18th International HLA and Immunogenetics Workshop: Report on the SNP‐HLA Reference Consortium (SHLARC) component

“…As a result, today's population in Finland is a genetic patchwork and a genetic outlier in Europe 20,21 . The Finnish MHC is characterized by a reduced allele pool and enrichment of alleles and haplotypes regarding HLA and MIC genes 22–24 . Several HLA haplotypes, common in Finland but rare or missing in other European populations, have been identified and named as Finnish enriched rare (FER) haplotypes 23 …”

“…20,21 The Finnish MHC is characterized by a reduced allele pool and enrichment of alleles and haplotypes regarding HLA and MIC genes. [22][23][24] Several HLA haplotypes, common in Finland but rare or missing in other European populations, have been identified and named as Finnish enriched rare (FER) haplotypes. 23 F I G U R E 2 Accuracy depends of the population origin, which reflects HLA allele diversity.…”