We stress the notion of statistical experiment, which is mandatory for quantum mechanics, and recall Ludwig's foundation of quantum mechanics, which provides the most general framework to deal with statistical experiments giving evidence for particles. In this approach particles appear as interaction carriers between preparation and registration apparatuses. We further briefly point out the more modern and versatile formalism of quantum theory, stressing the relevance of probabilistic concepts in its formulation. At last we discuss the role of macrosystems, focusing on quantum field theory for their description and introducing for them objective state parameters.