At the current stage of development of modern society, the problem of ensuring food security is becoming increasingly important and is rapidly becoming one of the key problems of both national and global nature. Its solution today is an important condition for creating an atmosphere of stability and well-being in the world as a whole, in each individual country or its region. In this regard, there is an objective need for a more detailed and in-depth study of the issues under consideration from practical and theoretical positions, which in turn, in our opinion, requires studying the issues of further development of scientific research in the field of food security both globally and at the national and regional levels, which have become very relevant today. According to the results of the research, priority directions of ensuring food security at the global and international levels have been identified from theoretical and practical positions, the current state of affairs and prospects for further development have been analyzed at the level of national food security under the influence of crisis sanctions and post-crisis factors, key problems of ensuring food security at the meso- and micro-levels have been identified, and approaches have been formed, ways and measures to resolve them.