Description of nighttime cough epochs in patients with stable COPD GOLD II&amp;ndash;IV

Fischer, Patrick; Groß, Volker; Kroenig, Johannes; Weissflog, Andreas; Hildebrandt, Olaf; Sohrabi, Keywan; Koehler, Ulrich

doi:10.2147/copd.s154539

Cited by 13 publications

(19 citation statements)

References 24 publications

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“…The LEOSound® Monitor has been studied in chronic obstructive pulmonary disease [9, 10], in children and adults with asthma [11], and in patients with obstructive sleep apnea [12], where it was used to monitor cough, wheeze, and obstructive sleep apneas. The LEOSound® Monitor is a battery-operated device that electronically records breath and lung sounds using four microphones.…”

Section: Methodsmentioning

confidence: 99%

Comparison of Nocturnal Cough Analysis in Healthy Subjects and in Patients with Cystic Fibrosis and Primary Ciliary Dyskinesia: A Prospective Observational Study

et al. 2018

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Background: Cough is a key symptom in patients with cystic fibrosis (CF) and primary ciliary dyskinesia (PCD). Objective: The study objectives were to test whether cough is related to parameters reflecting their disease severity and whether CF and PCD differ in cough frequency. Methods: In this prospective observational study, we used a microphone-based monitoring system (LEOSound® Monitor) to count the coughs in healthy subjects (HS) and in stable patients with CF and PCD (25 subjects per group) on 2 consecutive nights. Results: The median number of coughs/h in the HS, CF, and PCD groups was 0.0, 1.3, and 0.5 on the first night and 0.0, 2.3, and 0.2 on the second night, respectively. Patients with CF and PCD coughed more than HS (p < 0.001 and p = 0.009, respectively) and CF patients coughed more than PCD patients (p = 0.023). A multivariable mixed model analysis revealed forced expiratory volume in 1 s as an independent risk factor for increased cough frequency in patients. The reliability for repeated measurements was higher for cough epochs/h than for coughs/h (intraclass correlation coefficient: 0.75 and 0.49, respectively). Conclusions: Patients with CF cough more than patients with PCD. The cough frequency in CF and PCD is associated with parameters reflecting disease severity. Cough frequency is a possible endpoint in clinical trials and cough epochs/h may be more useful than coughs/h.

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Section: Methodsmentioning

confidence: 99%

Comparison of Nocturnal Cough Analysis in Healthy Subjects and in Patients with Cystic Fibrosis and Primary Ciliary Dyskinesia: A Prospective Observational Study

et al. 2018

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“…Wheezing is a sign of an uncontrolled level of asthma. Automatic detection and classification of cough and wheezing is useful in assisting physicians in the diagnosis and monitoring of acute and chronic respiratory diseases such as asthma, acute bronchitis and COPD [11,12,[16][17][18]. Grading of asthma control necessitates specifying the rate of [10].…”

Section: Discussionmentioning

confidence: 99%

Disease control in patients with asthma and respiratory symptoms (wheezing, cough) during sleep

Doenges

Kuckuck

Cassel

et al. 2020

asthma res and pract

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Introduction The Global Initiative for Asthma (GINA)-defined criteria for asthma control include questions about daytime symptoms, limitation of activity, nocturnal symptoms, need for reliever treatment and patients’ satisfaction. Patients with nocturnal symptoms like wheezing and cough often suffer from lower sleep quality and impaired daytime performance. The lack of an appropriate method for standardized and objective monitoring of respiratory symptoms leads to difficulties in asthma management. The aim of this study is to present a new method for automated wheeze and cough detection during sleep and to assess the actual level of asthma control by the Asthma Control Test (ACT). Methods Respiratory symptoms like wheezing and cough were recorded with the LEOSound-Monitor for one night in 55 asthmatic patients in their individual domestic setting. Patients were asked to assess their level of asthma subjectively with the ACT. The study consisted of 37 women and 18 men, with a mean age of 41 years, and a mean BMI of 27 kg/m2. Most of the patients had been taking an ICS/LABA combination and would resort to a SABA as their rescue medication. Results 60% of the participants were classed as having controlled, and 40% were classed as having partially- or uncontrolled asthma. During sleep wheezing was found in 8 of the 55 asthma patients (14.5%) and coughing was found in 30 patients (54.5%). The median ACT score in wheezing-patients was 14, while in non-wheezing patients it was 21. Uncontrolled asthma was found in 6 of the 8 wheezing-patients. Coughing versus non-coughing patients did not show a significant difference in the ACT-score (20, 22 respectively). Conclusion Wheezing is a sign of uncontrolled asthma. The ACT-score in wheezing patients is worse compared to patients without wheezing. LEOSound proofed to be a useful tool in providing an objective evaluation of respiratory symptoms, like coughing and wheezing. In clinical practice, this may allow an improvement in asthma therapy.

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“…Although new technology has been developed to monitor coughing during sleep in patients with COPD, more studies are needed to validate the results. Fisher et al 46 , using a LEOSound lung sound monitor, showed that coughing events were found in all the 30 COPD studied, but that most of the coughing periods were non-productive. This correlates with the fact that productive cough is predominantly found in the early morning after getting up from bed 47 .…”

Section: Methods To Assess and Measure Symptom Variabilitymentioning

confidence: 99%

Relevance of Symptom Variability for Control and Management of COPD

Soler-Cataluña¹,

Lόpez-Campos²

2021

BRN

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Physiological and cellular functions operate in a 24-hour cyclical pattern orchestrated by an endogenous process known as the circadian rhythm. Airway calibre exhibits a circadian variation with maximum values occurring around noon and minimum values in the early morning. The mechanisms behind the daily variation are complex, but it has been speculated that autonomic input to airway tissues via the vagal nerve plays an essential role. In chronic obstructive pulmonary disease (COPD), there is important daily variation of respiratory symptoms, which are present in approximately half of the patients. This time-dependent variability has important consequences since it has an impact on daily life physical activity, sleep quality, severity of symptoms, exacerbations or health-related quality of life, which in turn represents a component of instability within a period previously considered as relatively calm. This article reviews the symptomatic variability in COPD, its pathophysiological basis, characteristics, determinants, potential consequences and therapeutic implications.

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Description of nighttime cough epochs in patients with stable COPD GOLD II–IV

Cited by 13 publications

References 24 publications

Comparison of Nocturnal Cough Analysis in Healthy Subjects and in Patients with Cystic Fibrosis and Primary Ciliary Dyskinesia: A Prospective Observational Study

Comparison of Nocturnal Cough Analysis in Healthy Subjects and in Patients with Cystic Fibrosis and Primary Ciliary Dyskinesia: A Prospective Observational Study

Disease control in patients with asthma and respiratory symptoms (wheezing, cough) during sleep

Relevance of Symptom Variability for Control and Management of COPD

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