Description of the parasite Wucheria Bancrofti Microfilariae identified in follicular fluid following transvaginal oocyte retrieval

Brezina, Paul R.; Yunus, Fahd; García, Jairo E.; Zhao, Yulian

doi:10.1007/s10815-011-9538-4

Cited by 5 publications

(4 citation statements)

References 13 publications

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“…An alternative migration route used by microfilariae to arrive at the processus vaginalis may be via the lymphatic vessels; observed, for example, in Brugia malayi infections ( 42 ). Interestingly, microfilariae of Wuchereria bancrofti have also been shown to infect testicular tissue ( 43 , 44 ) and follicular fluid in humans ( 45 ).…”

Section: Discussionmentioning

confidence: 99%

Case report: Filarial infection of a parti-coloured bat: Litomosa sp. adult worms in abdominal cavity and microfilariae in bat semen

Pikula,

Piacek,

Bandouchova

et al. 2023

Front. Vet. Sci.

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BackgroundFilarial infections have been understudied in bats. Likewise, little is known about pathogens associated with the reproductive system in chiropterans. While semen quality is critical for reproductive success, semen-borne pathogens may contribute to reproductive failure.MethodsFor the first time we performed electroejaculation and used computer-assisted semen analysis to provide baseline data on semen quality in a parti-coloured bat (Vespertilio murinus).ResultsThe semen quality values measured in the V. murinus male appeared high (semen concentration = 305.4 × 106/mL; progressive and motile sperm = 46.58 and 60.27%, respectively). As an incidental finding, however, microfilariae were observed in the bat semen examined. At necropsy, eight adult filarial worms, later genetically identified as Litomosa sp., were found in the peritoneal cavity, close to the stomach, of the same particoloured bat male dying as a result of dysmicrobia and haemorrhagic gastroenteritis in a wildlife rescue centre. Histopathology revealed microfilariae in the testicular connective tissue and the epidydimal connective and fat tissues. A PCR assay targeting cytochrome c oxidase subunit 1 confirmed that adult worms from the peritoneal cavity and testicular microfilariae were of the same filarial species. Mildly engorged argasid mite larvae attached to the bat skin proved negative for filarial DNA and the adult filarial worms proved negative for endosymbiont Wolbachia.ConclusionWhile the standard filarial life cycle pattern involves a vertebrate definitive host and an invertebrate vector, represented by a blood-sucking ectoparasite, our finding suggests that microfilariae of this nematode species may also be semen-borne, with transmission intensity promoted by the polygynous mating system of vespertilionid bats in which an infected male mates with many females during the autumn swarming. Presence of microfilariae may be expected to decrease semen quality and transmission via this route may challenge the success of reproductive events in females after mating. Further investigation will be necessary to better understand the bat-parasite interaction and the life cycle of this filarial worm.

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Section: Discussionmentioning

confidence: 99%

Case report: Filarial infection of a parti-coloured bat: Litomosa sp. adult worms in abdominal cavity and microfilariae in bat semen

Pikula,

Piacek,

Bandouchova

et al. 2023

Front. Vet. Sci.

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“…[12][13][14][15] Microfilariae of W. bancrofti and other filarial species such as Loa loa and Mansonella perstans have been found in the follicular fluid and in cervicovaginal smears, but the impact of this presence on fertility is uncertain. [16][17][18][19] Results of a single community-wide study suggest that LF infection has no effect on fertility, despite a strong positive association being found between being microfilaremic and abnormal menstruation patterns in women aged ³ 30 years. 20 It has also been suggested that L. loa and M. perstans microfilaremia may affect the functions of the hormonal system, leading to delays in puberty, disturbances to the menstrual cycle, and infertility in older subjects.…”

Section: Introductionmentioning

confidence: 99%

Effect of Lymphatic Filariasis and Hookworm Infection on Pregnancy Course and Outcome in Women Living in the Democratic Republic of the Congo

Campillo

Chabot

Awaca-Uvon

et al. 2021

The American Journal of Tropical Medicine and Hygiene

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Little is known about the effect of helminth infections on the natural gynecological and pregnancy course. Our goal was to assess the relationship between Wuchereria bancrofti and hookworm (HW) infections with pregnancy course and outcome in a group of 82 women living in a rural area of the Democratic Republic of the Congo. Demographics and information on gynecological and obstetrical histories were collected retrospectively with standardized questionnaires. Wuchereria bancrofti and HW infections were diagnosed using a filarial antigen-detection test and the Kato–Katz method, respectively. Analyses consisted of multivariable logistic regressions adjusting for age, number of deliveries, and history of anthelmintic treatment (HAHT). The median age of study participants was 35 (interquartile range [IQR]: 30–44) years, and the median number of deliveries was five (IQR: 3–7). Wuchereria bancrofti and HW infection rates were 44.5% and 43.3%, respectively. Filarial antigenemia and HW infection were not significantly associated with the number of deliveries. The proportions of women with a history of pregnancy resulting in neonatal death, miscarriage, premature birth, and postpartum hemorrhage were 56%, 44%, 23%, and 36%, respectively. History of pregnancy associated with neonatal death was less frequent in women with HAHT, tended to be more frequent in women with filarial antigenemia, and was not associated with HW infection. None of the three other pregnancy events studied (miscarriage, premature birth, and postpartum hemorrhage) were associated with filarial antigenemia or HW infection. The positive association found between HAHT and lower risk of neonatal death warrants investigation in larger groups of women.

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“…[ 1 – 3 ] The species of identified filarial worms include Wuchereria bancrofti and Mansonella perstans . [ 1 – 2 ] All indexed cases are the migrant infertile women from endemic area. [ 1 – 2 ] However, the actual effect of filariasis at this site on reproductive health is not well documented and can be the future topic of research.…”

mentioning

confidence: 99%

“…[ 1 – 2 ] All indexed cases are the migrant infertile women from endemic area. [ 1 – 2 ] However, the actual effect of filariasis at this site on reproductive health is not well documented and can be the future topic of research. [ 3 ] However, this is an actual new concern in tropical medicine, travel medicine, and reproductive medicine.…”

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confidence: 99%

Filariasis in follicular fluid: A new concern of tropical infection in reproductive health

Wiwanitkit

2011

J Hum Reprod Sci

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Description of the parasite Wucheria Bancrofti Microfilariae identified in follicular fluid following transvaginal oocyte retrieval

Cited by 5 publications

References 13 publications

Case report: Filarial infection of a parti-coloured bat: Litomosa sp. adult worms in abdominal cavity and microfilariae in bat semen

Case report: Filarial infection of a parti-coloured bat: Litomosa sp. adult worms in abdominal cavity and microfilariae in bat semen

Effect of Lymphatic Filariasis and Hookworm Infection on Pregnancy Course and Outcome in Women Living in the Democratic Republic of the Congo

Filariasis in follicular fluid: A new concern of tropical infection in reproductive health

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