Descriptive Analysis of a Clinical Pharmacy Intervention to Improve the Appropriate Use of Stress Ulcer Prophylaxis in a Hospital Infectious Disease Ward

Khalili, Hossein; Dashti‐Khavidaki, Simin; Talasaz, Azita H.; Tabeefar, Hamed; Hendoiee, Narjes

doi:10.18553/jmcp.2010.16.2.114

Cited by 35 publications

(37 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…3,10,12,16,17,21 High prevalence of irrational prescribing in some institutes necessitated clinical pharmacist intervention, which could improve the prescription pattern of SUP administration in certain hospital wards. 22,23 …”

Section: Discussionmentioning

confidence: 99%

Variables Associated with Adherence to Stress Ulcer Prophylaxis in Patients Admitted to the General Hospital Wards: A Prospective Study

2017

View full text Add to dashboard Cite

Purpose: The dramatic increase in stress ulcer prophylaxis (SUP) prescribing patterns over the past several years has raised concerns regarding to their appropriate utilization. This prospective study attempted to evaluate the trend of adherence to stress ulcer prophylaxis from admission until discharge in non- Intensive care unit (ICU) setting. Additionally, we attempted to find those variables associated with appropriate SUP administration. Methods: Data collection was performed prospectively to evaluate 195 randomly selected adult patients who received SUP or had indication for that in non-ICU wards of one of the largest referral center in Iran, during 6 months. Adherence was studied according to widely accepted American Society of Health system Pharmacists (ASHP) guideline. Univariate and multivariate logistic regression was also performed to detect associations related to misuse of SUP. Results: We recognized total inappropriate use of SUP upon admission, during hospital stay and at discharge were somewhat identical at different time points (61%, 80% and 77.4% respectively). On the other hand, since small number of patients experienced SUP underutilization, unfortunately this was not possible to elucidate factors that may have effect on this flawed behavior. However, increasing age was identified to be significant variable in SUP overutilization. Conclusion: This prospective study highlighted inappropriate overutilization of SUP within non-critically ill patients and found factors which predicted this behavior. Adherence during hospital stay was also calculated for the first time in this study, which was related to SUP adherence upon hospital admission.

show abstract

Section: Discussionmentioning

confidence: 99%

Variables Associated with Adherence to Stress Ulcer Prophylaxis in Patients Admitted to the General Hospital Wards: A Prospective Study

2017

View full text Add to dashboard Cite

show abstract

“…A specific form was designed to gather patients' demographic data (including age, gender and weight), serum creatinine concentration, medical diagnosis at admission, any underlying disease, reason and duration of SUP prescription and type of prescribed AST. Prophylaxis was defined as sustained (>1 day) administration of an acid‐suppressive medicine (H2 blocker or PPIs) in the absence of active GI bleeding, based on medical record review …”

Section: Methodsmentioning

confidence: 99%

Impact of clinical pharmacy services on stress ulcer prophylaxis prescribing and related cost in patients with renal insufficiency

Mousavi

Dashti‐Khavidaki

Khalili

et al. 2012

International Journal of Pharmacy Practice

Self Cite

View full text Add to dashboard Cite

show abstract

“…Guide implementation (such as the ones used in this work) has been shown to decrease drug prescriptions, inappropriate use and associated costs (34). A study in the USA estimated annual savings of up to US$ 102,895 on patient care and US$ 11,333 on drug costs when stress-ulcer prophylaxis guides were use in an Intensive Care Unit (35), whilst a similar study in Canada demonstrated that daily drug costs were reduced from C$ 2.50/day to C$ 1.30/day by using these protocols (36).…”

Section: Discussionmentioning

confidence: 99%

“…The number of patients included (n = 778) greatly exceeds that of other described studies (24,(26)(27)(28). New research should be carried out on antiulcer prescriptions after hospital discharge, and comparisons of adequate prescribing at university hospitals vs. non-academic hospitals, as well as evaluating the impact of implementing drug prescription guidelines (27,28,34,35). It is necessary to carry out more studies on the economic consequences of drug inadequate use, especially in the antiulcer group.…”

Section: Discussionmentioning

confidence: 99%

An economic analysis of inadequate prescription of antiulcer medications for in-hospital patients at a third level institution in Colombia

Machado‐Alba

Castrillón-Spitia

Londoño-Builes³

et al. 2014

Rev. esp. enferm. dig.

View full text Add to dashboard Cite

Introduction:The prescription and costs of antiulcer medications for in-hospital use have increased during recent years with reported inadequate use and underused.Aim: To determine the patterns of prescription-indication and also perform an economic analysis of the overcost caused by the non-justified use of antiulcer medications in a third level hospital in Colombia.Materials and methods: Cross-sectional study of prescription-indication of antiulcer medications for patients hospitalized in "Hospital Universitario San Jorge" of Pereira during July of 2012. Adequate or inadequate prescription of the first antiulcer medication prescribed was determined as well as for others prescribed during the hospital stay, supported by clinical practice guidelines from the Zaragoza I sector workgroup, clinical guidelines from the Australian Health Department, and finally the American College of Gastroenterology Criteria for stress ulcer prophylaxis. Daily defined dose per bed/day was used, as well as the cost for 100 beds/day and the cost of each bed/drug. A multivariate analysis was carried out using SPSS 21.0.Results: 778 patients were analyzed, 435 men (55.9 %) and 343 women, mean age 56.6 ± 20.1 years. The number of patients without justification for the prescription of the first antiulcer medication was 377 (48.5 %), and during the whole in-hospital time it was 336 (43.2 %). Ranitidine was the most used medication, in 438 patients (56.3 %). The cost/month for poorly justified antiulcer medications was € 3,335.6. The annual estimated cost for inadequate prescriptions of antiulcer medications was € 16,770.0 per 100 beds.Conclusion: A lower inadequate prescription rate of antiulcer medications was identified compared with other studies; however it was still high and is troubling because of the major costs that these inadequate prescriptions generates for the institution.

show abstract

Descriptive Analysis of a Clinical Pharmacy Intervention to Improve the Appropriate Use of Stress Ulcer Prophylaxis in a Hospital Infectious Disease Ward

Cited by 35 publications

References 27 publications

Variables Associated with Adherence to Stress Ulcer Prophylaxis in Patients Admitted to the General Hospital Wards: A Prospective Study

Variables Associated with Adherence to Stress Ulcer Prophylaxis in Patients Admitted to the General Hospital Wards: A Prospective Study

Impact of clinical pharmacy services on stress ulcer prophylaxis prescribing and related cost in patients with renal insufficiency

An economic analysis of inadequate prescription of antiulcer medications for in-hospital patients at a third level institution in Colombia

Contact Info

Product

Resources

About