Descriptive analysis of and overall survival after surgical treatment of lung metastases

Abstract

OBJECTIVE: To describe demographic characteristics, surgical results, postoperative complications, and overall survival rates in surgically treated patients with lung metastases. METHODS: This was a retrospective analysis of 119 patients who underwent a total of 154 lung metastasis resections between 1997 and 2011. RESULTS: Among the 119 patients, 68 (57.1%) were male and 108 (90.8%) were White. The median age was 52 years (range, 15-75 years). In this sample, 63 patients (52.9%) presented with comorbidities, the most common being systemic arterial hypertension (69.8%) and diabetes (19.0%). Primary colorectal tumors (47.9%) and musculoskeletal tumors (21.8%) were the main sites of origin of the metastases. Approximately 24% of the patients underwent more than one resection of the lesions, and 71% had adjuvant treatment prior to metastasectomy. The rate of lung metastasis recurrence was 19.3%, and the median disease-free interval was 23 months. The main surgical access used was thoracotomy (78%), and the most common approach was wedge resection with segmentectomy (51%). The rate of postoperative complications was 22%, and perioperative mortality was 1.9%. The overall survival rates at 12, 36, 60, and 120 months were 96%, 77%, 56%, and 39%, respectively. A Cox analysis confirmed that complications within the first 30 postoperative days were associated with poor prognosis (hazard ratio = 1.81; 95% CI: 1.09-3.06; p = 0.02). CONCLUSIONS: Surgical treatment of lung metastases is safe and effective, with good overall survival, especially in patients with fewer metastases.

Surgery Versus Stereotactic Radiotherapy for Treatment of Pulmonary metastases. a Systematic Review of Literature

“…Apart from this exceptions, 5-years OS is usually greater in surgical studies and can be as high as 76%. Moreover, several surgical series describe rates of survival at 10 years reaching 40% [39][40][41][42][43], suggesting that a stabilization or eradication of disease can be obtained in some cases.…”

Surgical Treatment of Lung Metastases of Colorectal Carcinoma – Survival and Prognostic Factors

“…colorectal carcinoma -lung metastases -metastasectomy -survival [9]. Niektoré štúdie považujú VTS za ekvivalentnú metódu v pľúcnej metastazektómii [8], avšak podľa odporúčaní ESTS má peroperačná manuálna palpácia stále zásadný význam v detekcii intraparenchymálnych ložísk [10].…”

“…Za onkologicky radikálnu pľúcnu metastazektómiu je pokladaná resekcia, pri ktorej línie resekcie prebiehajú zdravým pľúcnym tkanivom. Zároveň má byť podľa možností resekcia pľúcneho parenchýmu čo najkonzervatívnejšia [9]. Rozsah resekcie pre metastázy je od atypickej klinovitej resekcie po rôzne typy anatomických pľúcnych resekcií.…”

Diagnostics of intrapulmonary metastases from colorectal cancer (literature survey)

“…The colorectal cancer keeps first place as an etiologic reason for performance of pulmonary metastases resection (76,77). It is established the low effectiveness of the chemotherapy in metastatic progress of the colorectal carcinoma.…”