Cavitation-induced shock wave, as might occur in the head during exposure to blast waves, was investigated as a possible damage mechanism for soft brain tissues. A novel experimental scheme was developed to visualize and control single bubble cavitation and its collapse, and the influence of this process on a nearby tissue surrogate was investigated. The experiment utilized a Hopkinson pressure bar system which transmits a simulated blast pressure wave (with over and under pressure components) to a fluid-filled test chamber implanted with a seed gas bubble. Growth and collapse of this bubble was visually recorded during passage of the blast wave with a high speed