Descriptive epidemiology of brain and central nervous system cancers in Central and South America

Piñeros, Marion; Sierra, Mónica S.; Izarzugaza, M. Isabel; Forman, David

doi:10.1016/j.canep.2016.04.007

Cited by 48 publications

(45 citation statements)

References 26 publications

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“…Brain and central nervous system (CNS) malignancies are uncommon neoplasms associated with differing pathological causes, molecular pathways and immunological responses [ 146 ]. The innate immunity has an important role in cancer metastasis in the CNS [ 147 ].…”

Section: Role Of the Nlrp3 Inflammasome In Cancermentioning

confidence: 99%

Role of the NLRP3 inflammasome in cancer

et al. 2018

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Inflammasomes are large intracellular multi-protein signalling complexes that are formed in the cytosolic compartment as an inflammatory immune response to endogenous danger signals. The formation of the inflammasome enables activation of an inflammatory protease caspase-1, pyroptosis initiation with the subsequent cleaving of the pro-inflammatory cytokines interleukin (IL)-1β and proIL-18 to produce active forms. The inflammasome complex consists of a Nod-like receptor (NLR), the adapter apoptosis-associated speck-like (ASC) protein, and Caspase-1. Dysregulation of NLRP3 inflammasome activation is involved tumor pathogenesis, although its role in cancer development and progression remains controversial due to the inconsistent findings described. In this review, we summarize the current knowledge on the contribution of the NLRP3 inflammasome on potential cancer promotion and therapy.

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Section: Role Of the Nlrp3 Inflammasome In Cancermentioning

confidence: 99%

Role of the NLRP3 inflammasome in cancer

et al. 2018

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“…En Centro América y América del Sur, para el 2012 se re portó que los tumores del sistema nervioso central eran la décima primera causa de morbilidad y mortalidad; luego en el 2016 se reportaron 12 000 casos de tumores malig nos, con tasas de incidencia desde 0.3 a 6.2 casos por 100 000 habitantes [6,7].…”

Section: Introductionunclassified

Relación Entre El Coeficiente De Difusión Aparente y la celularidad. [Relación Entre El Coeficiente De Difusión Aparente yLa Celularidad De Gliomas en Centro de tercer nivel de Panamá]

et al. 2020

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Resumen Introducción: Los gliomas son tumores malignos altamente celulares del sistema nervioso central. Su grado histológico preoperatorio es de utilidad en el manejo quirúrgico, por lo que la resonancia magnética con secuencias avanzadas intenta brindar mayor información tumoral. Objetivo: Relacionar el coeficiente aparente de difusión (CAD) y celularidad de los gliomas de pacientes entre enero 2015 a diciembre 2017. Metodología:Retrospectivamente se obtuvieron de archivos clínicos la edad, sexo, tipo, grado histológicoy sitio anatómico. Se calculó el CAD en 5mm2 en los estudios de resonancia magnética preoperatorias y se utilizó las laminillas para conteo de celularidad en 5mm2 digitalmente. Se utilizó análisis estadísticos descriptivos y coeficiente de correlación entre CDA con celularidad. Se utilizaron valores de p < 0.05 para significancia estadística. Resultados: 46 casos fueron incluidos, 56.5% fueron hombres. El rango de 41-64 años fueron los más afectados. El glioblastoma fue el tipo histológico más frecuente (47.8%), así como los gliomas de alto grado (73.9%). El 95.7% fueron supratentoriales. La celularidad promedio fue de 3970 ± 2900 vs 2436 ± 948 núcleos/5mm2 (p = 0.13), con valores promedio de CDA mínimo de 0.813 x 10-3 ± 0.229 mm2/s vs 1.052 x 10-3 ± 0.196 mm2/s (p = 0.002), para los gliomas de alto y bajo grado respectivamente. La correlación entre CDA y celularidad fue débil (R = - 0.13, p = 0.37). Conclusión: Existe correlación débil inversamente proporcional entre el CDA y la celularidad con distinción de gliomas de bajo y alto grado con valores de CDA mínimos. Abstract Introduction: Gliomas are highly cellular malignant tumors of the central nervous system. Itspreoperative histological grade is useful in surgical management,so magnetic resonance imaging with advanced sequences tries to provide more tumor information. Objective:Correlateapparent diffusion coefficient (ADC) and cellularity of gliomas of patients between January 2015 to December 2017. Methodology:Data of age, sex, type, histologic grade and anatomic site were retrospectively obtained from clinical archives.The preoperative magnetic resonance ADC was calculated in a 5 mm2 region of interest and the microscope slides were used for the cellularity digitally count in 5 mm2. Descriptive statistical analysis and correlation coefficient between ADC and cellularity were used. Values of p <0.05 were used for statistical significance. Results: 46 cases were included, 56.5% were men. The 41-64 years ranges were the most affected. Glioblastoma was the most frequent histological type (47.8%), as well as high grade gliomas (73.9%). 95.7% were supratentorial. The average cellularity was 3970 ± 2900 vs 2436 ± 948 nuclei/ 5mm2 (p = 0.13), with average minimum ADC values of 0.813 x 10-3 ± 0.229 mm2/s vs 1052 x 10-3 ± 0.196 mm2/s (p = 0.002), for high- and low-grade gliomas, respectively. The correlation between ADC and cellularity was weak (R = - 0.13, p = 0.37). Conclusions:There is a weak inversely proportional correlation between ADC and cellularity. With distinction of low- and high-grade gliomas with minimum ADC values.

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“…Glioma is one type of intracranial space-occupying lesions with relatively high incidence [ 51 , 55 , 80 ]. In general, the management of glioma consists of imaging, surgery, and other postoperative treatment modalities [ 34 , 38 ].…”

Section: Introductionmentioning

confidence: 99%

MRI combined with PET-CT of different tracers to improve the accuracy of glioma diagnosis: a systematic review and meta-analysis

Yang

et al. 2017

Neurosurg Rev

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Based on studies focusing on positron emission tomography (PET)-computed tomography (CT) combined with magnetic resonance imaging (MRI) in the diagnosis of glioma, we conducted a systematic review and meta-analysis evaluating the pros and cons and the accuracy of different examinations. PubMed and Cochrane Library were searched. The search was conducted until April 2017. Two reviewers independently conducted the literature search according to the criteria set initially. Based on the exclusion criteria, 15 articles are included in this study. Of all studies that used MRI examination, there are five involving 18F-fluorodeoxyglucose-PET, five involving 11C-methionine-PET, five involving 18F-fluoro-ethyl-tyrosine-PET, and three involving 18F-fluorothymidine-PET. Due to the limitations such as lack of data, small sample size, and unrepresentative studies, we use a non-quantitative methodology. MRI examination can provide the anatomy information of glioma more clearly. PET-CT examinations based on tumor metabolism using different tracers have more advantages in determining the degree of glioma malignancy and boundaries. However, information provided by PET-CT of different tracers is not the same. With respect to the novel hybrid MRI/PET examination equipment proposed in recent years, the combination of MRI and PET-CT can definitively improve the diagnostic accuracy of glioma.

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Descriptive epidemiology of brain and central nervous system cancers in Central and South America

Cited by 48 publications

References 26 publications

Role of the NLRP3 inflammasome in cancer

Role of the NLRP3 inflammasome in cancer

Relación Entre El Coeficiente De Difusión Aparente y la celularidad. [Relación Entre El Coeficiente De Difusión Aparente yLa Celularidad De Gliomas en Centro de tercer nivel de Panamá]

MRI combined with PET-CT of different tracers to improve the accuracy of glioma diagnosis: a systematic review and meta-analysis

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