Descriptive epidemiology of small intestinal malignancies: the German Cancer Registry experience

Abstract

In the first population-based analysis of certain epidemiologic features of primary malignancies of the small intestine in Germany, we used data from the Saarland Cancer Registry (1982–1993) and from the former National Cancer Registry of the German Democratic Republic (1976–1989). The age-standardized incidence rates for ages 0–74 years is 3.3–6.2 per million per year. The average incidence rates of the federal state Saarland are for men about 1.3 times and for women about 1.4 times the rate of the former German Democratic Republic. After the age of 30 years, the incidence rates increased with increasing age. Incidence rates for carcinoids levelled off after the age of 54 years. Rates for men were 35–40% higher than for women after adjusting for age. The risk for carcinomas, malignant carcinoids and malignant lymphoma were higher for men than for women. © 1999 Cancer Research Campaign

Small Intestinal Cancer: a Population-Based Study of Incidence and Survival Patterns in the United States, 1992 to 2006

“…An association of small intestinal lymphoma with human immunodeficiency virus (HIV) infection is suggested by the male predominance, age pattern, HIV-associated histologies, and extranodal subsite, as previously described (30-32). Notably, a similar peak in age-specific IRs is not apparent in studies of small intestinal lymphoma largely encompassing calendar years prior to the HIV pandemic (1, 14). With the introduction of highly active antiretroviral therapy (HAART) in 1996, non-Hodgkin lymphoma IRs have declined in Western countries (30, 31).…”

“…In general, higher small intestinal cancer IRs have been described among males in North America, Europe, Asia, and Central/South America, with exceptions noted in Iceland, Italy, Poland, Brazil, Australia, and Japan, where IRs are higher among females (2, 8, 14). The male predominance of small intestinal cancers is similar to that described for carcinomas at many other primary sites, a pattern which is attributed, in part, to environmental, endogenous, and behavioral factors that differ by gender (25).…”

“…In contrast to multiple studies that have evaluated temporal trends of small intestinal cancers (1, 4-7, 10, 11), fewer studies have described age-specific incidence according to histology (1, 8, 10, 14), and none have considered age-specific rates according to subsite. Although multiple series have described racial patterns among Blacks and Whites (2, 4, 6, 8, 10, 12), age-specific incidence rates of small intestinal cancers among other racial/ethnic groups, including Hispanics and Asians/Pacific Islanders (APIs) have rarely been reported (15).…”

Incidence of Small Bowel Cancer in the United States and Worldwide: Geographic, Temporal, and Racial Differences

“…However, secular trends tend to vary by geographic region, suggesting that these increases may, in fact, be real. For example, while the rates of adenocarcinomas and carcinoid tumors in the U.S. have been rising, incidence rates in Germany have not been increasing [17]. A Canadian study [18] did not find increasing trends for histologic types of small bowel cancer, except for a small increasing trend in malignant lymphomas, and a study in Denmark of carcinoid tumors [19] also found no clearly discernible increase.…”

Blood loss anemia due to adenocarcinoma of the jejunum: a case report and review of the literature

“…Data from Germany suggests an annual incidence of small bowel adenocarcinomas of 2.2-5.7 per million people each year [7].…”