Descriptive Epidemiology of Thyroid Cancers in Togo

Darré, Tchin; Amana, B; Pegbessou, Essobozou; Bissa, Haréfétéguéna; Amégbor, Koffi; Boko, E; Kpemessi, Eyawelohn; Napo‐Koura, Gado

doi:10.7314/apjcp.2015.16.15.6715

Cited by 23 publications

(36 citation statements)

References 14 publications

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“…This age at presentation in our current study is in agreement with a previous Togolese study were the mean age at diagnosis of cancer was 50 years [10]. This is also similar to the mean age reported in Ghanaian patients at Korle bu Hospital [16] and in Indian women [17], but different from the relatively younger age of women with breast cancer reported in several studies in others countries in Africa [12,[18][19][20][21][22].…”

Section: Discussionsupporting

confidence: 92%

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Breast Cancer in Togolese Women: Immunohistochemistry Subtypes

ADANI-IFE¹,

AMEGBOR²,

DOH³

et al. 2020

Preprint

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Background Molecular classification of breast cancer is an important factor for prognostic and clinical outcome. There are no data regarding molecular breast cancer subtypes among Togolese women. The objective of this study was to evaluate the expression of ER, PR, HER2 and molecular subtypes of breast cancer receptor in Togolese patients and to establish the correlation between clinical and histological data and molecular types. Methods Clinicopathologic data of patients were collected from clinical records. Immunohistochemistry biomarkers (ER, PR and HER2) were assessed in patients who have been diagnosed with invasive breast cancer from March 2016 to March 2020 in the department of oncology. The analysis of variance and the Chi-square Test were used to analyze the data. Results A total of 117 cases were collected. Mean age of patients was 52.05 ± 12.38 with an age range of 30 to 85 years. Half of patients were over 50 years old and majority (70.9%) was postmenopausal. More than half of patients (52.1%) presented with T3-T4tumors.The most common histologic subtype of breast cancer was invasive ductal carcinoma of no special type (95.7%). Tumors grade 2 were predominant (51.3%) followed by grade 3 (42.7%). Advanced carcinomas were found in 69 patients (59%). The percentage of ER+, PR + and HER2 positive tumors was 50.4%, 37.6% and 15.4% respectively. The predominant molecular subtype was Luminal A (42.7%) followed by Triple negative (41.9%), Luminal B subtype (9.4%) and HER2 enriched (6%). There was significant association between tumor size and breast cancer subtypes (p = 0.026) but no correlation was found with age, stage, menopausal status and histologic grade. Conclusion Breast carcinoma in our patients are high grade tumors and are diagnosed at advanced stage. Luminal A and triple negative are the two predominant breast cancer subtypes in Togolese women. Consequently, Receptor testing availability should be a priority in order to offer the best breast cancer treatment.

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Section: Discussionsupporting

confidence: 92%

“…In Togo, Breast cancer is the rst cancer in women and is currently a major public health problem [9,10].…”

Section: Introductionmentioning

confidence: 99%

Breast Cancer in Togolese Women: Immunohistochemistry Subtypes

ADANI-IFE¹,

AMEGBOR²,

DOH³

et al. 2020

Preprint

Self Cite

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“…Similarly, it is ranked the third most common among Kuwaiti women and second most common among Saudi women 12 . The female predominance observed in this study is similar to those of the previous studies from KSA, UAE, Yemen, Kuwait, Poland, Togo, Turkey, and Brazil 7,9,10,[13][14][15][16][17] . In contrast, thyroid cancer is the 16th most common among females in Ireland 18 .…”

Section: Discussionsupporting

confidence: 91%

Thyroid Surgeries in a Single Centre, 2010 - 2014

Khuzaie¹,

Kamal²,

Alboosta³

2018

BMB

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Background: Thyroid surgery is the preferred modality of treatment in malignant and benign thyroid disease including papillary thyroid cancer and multinodular goiter. Objective: To describe the epidemiology of surgically treated thyroid disease in a single center, the cytological and histological patterns and assess the sensitivity and specificity of fine-needle aspiration cytology (FNAC) in diagnosing thyroid nodules with malignant potentials. Design: A Retrospective Study.

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“…Breast cancer is the most commonly diagnosed cancer among women in Ethiopia, as in other parts of Africa 1–4. In Addis Ababa, the capital city of Ethiopia, breast cancer accounts for one-third of all female cancers 1.…”

Section: Introductionmentioning

confidence: 99%

Time intervals experienced between first symptom recognition and pathologic diagnosis of breast cancer in Addis Ababa, Ethiopia: a cross-sectional study

et al. 2019

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ObjectivesThis study aimed to estimate the magnitude of patient and diagnostic delays and associated factors among women with breast cancer in Addis Ababa.DesignThis is a cross-sectional study.Settings and participantsAll women newly diagnosed with breast cancer in seven major healthcare facilities in Addis Ababa (n=441) were included in the study.Main outcomes and measuresPatient interval (time from recognition of first symptom to medical consultation) and diagnostic interval (time from first consultation to diagnosis). Patient intervals >90 days and diagnostic intervals >30 days were considered delays, and associated factors were determined using multivariable Poisson regressions with robust variance.ResultsThirty-six percent (95% CI [31.1%, 40.3%]) of the patients had patient intervals of >90 days, and 69% (95% CI [64.6%, 73.3%]) of the patients had diagnostic intervals of >30 days. Diagnostic interval exceeded 1 year for 18% of patients. Ninety-five percent of the patients detected the first symptoms of breast cancer by themselves, with breast lump (78.0%) as the most common first symptom. Only 8.0% were concerned about cancer initially, with most attributing their symptoms to other factors. In the multivariable analysis, using traditional medicine before consultation was significantly associated with increased prevalence of patient delay (adjusted prevalence ratio (PR) = 2.13, 95% CI [1.68, 2.71]). First consultation at health centres (adjusted PR = 1.19, 95% CI [1.02, 1.39]) and visiting ≥4 facilities (adjusted PR = 1.24, 95% CI [1.10, 1.40]) were associated with higher prevalence of diagnostic delay. However, progression of symptoms before consultation (adjusted PR = 0.73, 95% CI [0.60, 0.90]) was associated with decreased prevalence of diagnostic delay.ConclusionsPatients with breast cancer in Addis Ababa have prolonged patient and diagnostic intervals. These underscore the need for public health programme to increase knowledge about breast cancer symptoms and the importance of early presentation and early diagnosis among the general public and healthcare providers.

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Descriptive Epidemiology of Thyroid Cancers in Togo

Cited by 23 publications

References 14 publications

Breast Cancer in Togolese Women: Immunohistochemistry Subtypes

Breast Cancer in Togolese Women: Immunohistochemistry Subtypes

Thyroid Surgeries in a Single Centre, 2010 - 2014

Time intervals experienced between first symptom recognition and pathologic diagnosis of breast cancer in Addis Ababa, Ethiopia: a cross-sectional study

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